BACKGROUND: Histoplasmosis is an infection caused by the dimorphic fungus Histoplasma capsulatum and primarily presents with pulmonary symptoms. Immunocompromised individuals are at high risk for contracting disseminated histoplasmosis, which can be fatal if left untreated.
CASE: We present a case involving a 50-year-old woman with acquired immunodeficiency syndrome with an ulcerated vulvar lesion concerning for carcinoma. Extensive workup revealed disseminated histoplasmosis without pulmonary manifestations. She was treated with an extended course of an antifungal agent. Her vulvar lesion resolved.
CONCLUSION: Vulvar histoplasmosis is a rare etiology of vulvar pathology but one that should be considered in immunocompromised patients.
Histoplasmosis can present as genital lesions in immunocompromised patients.
Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama.
Corresponding author: Megan M. Shine, MD, University of Alabama at Birmingham, Department of Obstetrics and Gynecology, 1700 6th Avenue South, Birmingham, AL 35233; e-mail: firstname.lastname@example.org.
Financial Disclosure The authors did not report any potential conflicts of interest.