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Intraperitoneal Chemotherapy in a Pregnant Woman With Ovarian Cancer

Smith, Esther R. MD; Borowsky, Mark E. MD; Jain, Vanita Dharan MD

doi: 10.1097/AOG.0b013e31828a845a
Case Report

BACKGROUND: Ovarian cancer diagnosed in pregnancy is rare. There is limited evidence to guide the choice of optimal chemotherapeutic management for treatment of disease during pregnancy.

CASE: A 36-year-old primigravid woman was diagnosed with stage IIB grade III serous adenocarcinoma at 12 weeks of gestation. After extensive counseling, she opted for intraperitoneal chemotherapy. She received four cycles during the course of the pregnancy, and treatment was complicated by thrombocytopenia and mild preeclampsia. Delivery occurred by cesarean at 37 weeks of gestation, resulting in the birth of a live male neonate weighing 4 pounds 11 ounces with bilateral congenital talipes equinovarus.

CONCLUSION: Pregnant women with ovarian cancer should be offered the opportunity to maximize their survival, including standard chemotherapeutic regimens used in nonpregnant patients.

Pregnant women with ovarian cancer should be offered the opportunity to maximize their survival, including standard chemotherapeutic regimens used in nonpregnant patients.

A Woman's Place, Fayetteville, North Carolina; and Christiana Care Health System, Newark, Delaware.

Corresponding author: Esther R. Smith, MD, A Woman's Place, 2053 Valley Gate Drive, Suite 201, Fayetteville, NC 28304; e-mail: estrita@gmail.com.

Financial Disclosure The authors did not report any potential conflicts of interest.

© 2013 by The American College of Obstetricians and Gynecologists.