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Repeated Spontaneous Pregnancies in 45,X Turner Syndrome

Mortensen, Kristian Havmand MD; Rohde, Marianne Daniel MD; Uldbjerg, Niels MD, PhD, Professor; Gravholt, Claus Højbjerg MD, PhD

doi: 10.1097/AOG.0b013e3181cb5b2a
Case Reports

BACKGROUND: Spontaneous pregnancy rarely occurs in women with Turner syndrome, and poor maternal outcomes are prominent in these women.

CASES: We report two women with 45,X Turner syndrome who had a total of four spontaneous pregnancies. Maternal and fetal outcomes were good despite maternal comorbidities. Cesarean deliveries were performed in two of the pregnancies because of aortic dilatation and fetopelvic disproportion. Both cases were initially diagnosed as primary amenorrhea (absent pubarche and menarche with serological hypogonadism).

CONCLUSION: Repeated spontaneous pregnancies occur in women with 45,X Turner syndrome. Poor maternal outcome is not the rule.

Repeated spontaneous pregnancies with good maternal and fetal outcomes may occur in women with amenorrheal hypogonadal 45,X Turner syndrome.

From the Medical Department M (Diabetes and Endocrinology) and Research Laboratories, Aarhus University Hospital, Aarhus Hospital NBG; and Department of Obstetrics and Gynecology, Aarhus University Hospital, Skejby Hospital, Denmark.

Corresponding author: Kristian Havmand Mortensen, MD, Medical Department M (Diabetes and Endocrinology) and Research Laboratories, Nørrebrogade 44, Aarhus University Hospital, Aarhus Hospital NBG, DK–8000 Aarhus C; e-mail: kristian.havmand@ki.au.dk.

Financial Disclosure The authors did not report any potential conflicts of interest.

© 2010 The American College of Obstetricians and Gynecologists