You could be reading the full-text of this article now if you...

If you have access to this article through your institution,
you can view this article in

ACOG MEMBER SUBSCRIPTION ACCESS

If you are an ACOG Fellow and have not logged in or registered to Obstetrics & Gynecology, please follow these step-by-step instructions to access journal content with your member subscription.

Primary Peritoneal Cancer After Bilateral Salpingo-Oophorectomy in Two Patients With Lynch Syndrome

Schmeler, Kathleen M. MD1; Daniels, Molly S. MS2; Soliman, Pamela T. MD, MPH1; Broaddus, Russell R. MD, PhD3; Deavers, Michael T. MD3; Vu, Thuy M. MS2; Chang, George J. MD, MS4; Lu, Karen H. MD1

Obstetrics & Gynecology:
doi: 10.1097/AOG.0b013e3181b6f4f9
Case Reports
Abstract

BACKGROUND: Women with Lynch syndrome or hereditary nonpolyposis colorectal carcinoma (HNPCC) have a 40–60% lifetime risk of endometrial cancer and a 7–12% lifetime risk of ovarian cancer. Risk-reducing surgery, including hysterectomy and bilateral salpingo-oophorectomy (BSO), is currently recommended once child bearing is complete. We describe two cases of primary peritoneal cancer after BSO in women with Lynch syndrome or HNPCC.

CASES: The first patient was a 44-year-old woman who underwent hysterectomy with BSO for benign disease. She presented 12 years later with a pelvic mass and was diagnosed with a high-grade serous primary peritoneal cancer. Genetic testing showed a mutation in the MSH2 DNA mismatch repair gene. The second case was a 58-year-old woman who had a hysterectomy and BSO for endometrial cancer. She developed a high-grade serous primary peritoneal cancer 8 years later and was found to have a mutation in the PMS2 DNA mismatch repair gene.

CONCLUSION: Women with Lynch syndrome or HNPCC should be counseled that they may be at risk for developing primary peritoneal cancer despite undergoing gynecologic cancer risk-reducing surgery. The magnitude of this risk remains to be determined.

In Brief

Women with Lynch syndrome or hereditary nonpolyposis colorectal carcinoma should be counseled that they may be at risk for developing primary peritoneal cancer despite undergoing gynecologic cancer risk-reducing surgery.

Author Information

From the Departments of 1Gynecologic Oncology, 2Clinical Cancer Genetics, 3Pathology, and 4Surgical Oncology, the University of Texas M. D. Anderson Cancer Center, Houston, Texas.

The authors thank Dr. Raja Luthra for performing microsatellite instability testing on the tumor specimens.

Corresponding author: Kathleen M. Schmeler, MD, Department of Gynecologic Oncology, The University of Texas M.D. Anderson Cancer Center, PO Box 301439, Unit 1362, Houston, TX 77230-1439; e-mail: kschmele@mdanderson.org.

Financial Disclosure The authors did not report any potential conflicts of interest.

© 2010 The American College of Obstetricians and Gynecologists