Obstetrics & Gynecology

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Obstetrics & Gynecology:
doi: 10.1097/AOG.0b013e3181c51ed0
Case Reports

Epstein-Barr Virus–Associated Uterine Leiomyosarcoma in an Adult Lung Transplant Patient

Sunde, Jan MD; Chetty-John, Shilpa MD; Shlobin, Oksana A. MD; Boice, Charles R. MD

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Abstract

BACKGROUND: Multiple viruses have been associated with carcinogenesis in solid-organ transplant patients. Although Epstein-Barr virus (EBV) has been associated with lymphomas in immunocompromised patients, an association with smooth muscle tumors recently has been described.

CASE: An EBV immunoglobulin G–positive woman underwent bilateral lung transplant for sarcoidosis. She was placed on immunosuppression and prophylaxis for opportunistic infections. She presented 5 months later with an EBV-positive uterine leiomyosarcoma. Postoperative therapy included a decrease in immunosuppression and antiviral therapy. Recurrence was noted after 1 year; the patient developed sepsis while undergoing chemotherapy and declined further therapy.

CONCLUSION: Epstein-Barr virus–associated leiomyosarcoma can occur in the uterus in immunosuppressed patients.

© 2010 The American College of Obstetricians and Gynecologists

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