Skip Navigation LinksHome > August 2009 - Volume 114 - Issue 2, Part 2 > Endometrial Cancer in an Adolescent: A Possible Manifestatio...

ACOG MEMBER SUBSCRIPTION ACCESS

If you are an ACOG Fellow and have not logged in or registered to Obstetrics & Gynecology, please follow these step-by-step instructions to access journal content with your member subscription.

Obstetrics & Gynecology:
doi: 10.1097/AOG.0b013e31819dade8
Case Reports

Endometrial Cancer in an Adolescent: A Possible Manifestation of Cowden Syndrome

Schmeler, Kathleen M. MD1; Daniels, Molly S. MS2; Brandt, Amanda C. MS2; Lu, Karen H. MD1

Collapse Box

Abstract

BACKGROUND: Cowden syndrome is an autosomal dominant disorder characterized by the development of multiple intestinal hamartomas, distinctive mucocutaneous lesions, and an increased risk of endometrial, breast, and thyroid cancer.

CASE: An adolescent girl whose mother had a known germline PTEN mutation presented with abnormal vaginal bleeding and was diagnosed with a grade 2 endometrial adenocarcinoma. She underwent a robotic hysterectomy and was found to have no myometrial invasion or distant disease. Genetic testing revealed the patient to have the familial germline PTEN mutation.

CONCLUSION: The strikingly young age of onset of this patient’s endometrial cancer highlights the need for additional study to better understand Cowden syndrome and to determine what endometrial cancer screening and preventive strategies are needed.

© 2009 The American College of Obstetricians and Gynecologists

Login

ACOG MEMBER SUBSCRIPTION ACCESS

If you are an ACOG Fellow and have not logged in or registered to Obstetrics & Gynecology, please follow these step-by-step instructions to access journal content with your member subscription.

Article Tools

Share