For women with end-stage organ failure, transplantation is an established therapeutic option. Pregnancy after solid organ transplantation is no longer uncommon, especially with the recent advances in transplantation surgery and the availability of newer immunosuppressants. This article will review preconceptional counseling, common pregnancy complications, prenatal and intrapartum considerations, outcome by organ, immunosuppressant therapies, and neonatal outcomes based on data available from case series and voluntary registries. Some recommendations are provided to assist in the management of pregnancies after solid organ transplantation.
Data from retrospective series and voluntary registries suggest that the majority of women will have successful pregnancies without allograft dysfunction after solid organ transplantation.
From the Departments of Obstetrics, Gynecology, & Reproductive Sciences, University of Texas Medical School at Houston, Houston, Texas; and Washington Hospital Center, Washington, DC.
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Corresponding author: Joan M. Mastrobattista, MD, Department of Obstetrics, Gynecology, & Reproductive Sciences, Division of Maternal-Fetal Medicine, University of Texas Medical School at Houston, 6431 Fannin, Suite 3.604, Houston, TX 77030; e-mail: Joan.M.Mastrobattista@uth.tmc.edu.
Financial Disclosure The authors have no potential conflicts of interest to disclose.