Obstetrics & Gynecology

Skip Navigation LinksHome > February 2008 - Volume 111 - Issue 2, Part 1 > Twin Chorionicity and the Risk of Stillbirth
Obstetrics & Gynecology:
doi: 10.1097/AOG.0b013e318160d65d
Original Research

Twin Chorionicity and the Risk of Stillbirth

Lee, Young Mi MD; Wylie, Blair J. MD; Simpson, Lynn L. MD; D'Alton, Mary E. MD

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Abstract

OBJECTIVE: To estimate the effect of chorionicity on the risk of stillbirth in twins.

METHODS: A retrospective cohort analysis was performed of all twin deliveries of at least 24 weeks of gestation at a single tertiary care center from December 2000 to May 2007. The risk of fetal death with advancing gestation was calculated for monochorionic-diamniotic twins and for dichorionic-diamniotic twins. Overall in utero survival was compared by using Kaplan-Meier analysis and a hazards ratio with 95% confidence intervals estimated to assess the degree of difference. Pregnancies affected by growth abnormalities, anomalies, or twin-twin transfusion syndrome were subsequently excluded and survival by chorionicity similarly compared within these “apparently normal” gestations.

RESULTS: Data from 1,000 consecutive twin pairs (196 monochorionic-diamniotic twins and 804 dichorionic-diamniotic twins) were analyzed. Stillbirths occurred in seven (3.6%) monochorionic-diamniotic and nine (1.1%) dichorionic-diamniotic twin pairs. Monochorionic-diamniotic twins had a higher risk of stillbirth compared with dichorionic-diamniotic twins, both overall (log-rank P=.004) and at each gestational age after 24 weeks, with this risk persisting in the subset of 771 (130 monochorionic-diamniotic twins and 641 dichorionic-diamniotic twins) “apparently normal” twins (log-rank P=.039).

CONCLUSION: Monochorionicity has a negative effect on the in utero survival of twins, even among monochorionic-diamniotic twins without abnormalities.

LEVEL OF EVIDENCE: II

© 2008 The American College of Obstetricians and Gynecologists

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