Obstetrics & Gynecology

Skip Navigation LinksHome > May 2004 - Volume 103 - Issue 5, Part 2 > Use of a Hemoglobin-Based Oxygen Carrier in the Treatment of...

ACOG MEMBER SUBSCRIPTION ACCESS

If you are an ACOG Fellow and have not logged in or registered to Obstetrics & Gynecology, please follow these step-by-step instructions to access journal content with your member subscription.

Obstetrics & Gynecology:
Case Reports

Use of a Hemoglobin-Based Oxygen Carrier in the Treatment of Severe Anemia

Shander, Aryeh MD*; Alalawi, Raed MD†; Seeber, Petra MD‡; Lui, John MD*

Collapse Box

Abstract

BACKGROUND: Hemoglobin-based oxygen carriers hold promise for the treatment of acute anemia.

CASE: We report a patient with severe dysfunctional uterine bleeding. During her hospitalization, her lowest hemoglobin level was 3.1 g/dL, with a hematocrit of 9.3%. An investigational product, o-raffinose cross-linked human hemoglobin solution (hemoglobin raffimer), was infused along with ongoing high-dose recombinant human erythropoietin and estrogen. The time until the patient's own hematopoiesis provided sufficient red blood cell mass was successfully managed by reducing oxygen demand and providing multiple hemoglobin-based oxygen carrier infusions. After hemoglobin-based oxygen carrier administration, transient pulmonary hypertension and fever were noted. She was discharged after corrective surgery 7 days after hemoglobin-based oxygen carrier administration with a hemoglobin level of 7.8 g/dL.

CONCLUSION: The hemoglobin level–based oxygen carrier improved oxygen delivery and permitted uterine corrective surgery.

© 2004 The American College of Obstetricians and Gynecologists

Login

 

Looking for ABOG articles? Visit our ABOG MOC II collection. The selected Green Journal articles are free through the end of the calendar year.

ACOG MEMBER SUBSCRIPTION ACCESS

If you are an ACOG Fellow and have not logged in or registered to Obstetrics & Gynecology, please follow these step-by-step instructions to access journal content with your member subscription.

Article Tools

Share

Article Level Metrics