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Obstetrics & Gynecology:
Case Reports

A Rare Drug Reaction to Methotrexate After Treatment for Ectopic Pregnancy

Straka, Michele DO*; Zeringue, Ernest MD*; Goldman, Mindy MD†

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BACKGROUND: Ectopic pregnancies are commonly diagnosed and treated in physicians’ offices. In the hemodynamically stable patient, therapy often includes treatment with methotrexate. Well-known adverse effects of this drug include mucositis, abdominal cramping, and malaise. We report a case of a rare drug reaction after treatment with methotrexate.

CASE: A 34-year-old, gravida 2, para 0, at 7 weeks of gestation by last menstrual period was diagnosed with an ectopic pregnancy and treated with methotrexate. The patient had an anaphylactoid reaction shortly after administration of methotrexate.

CONCLUSION: Methotrexate is a commonly used therapy for ectopic pregnancies in the outpatient setting. Practitioners should be aware of the potential adverse reactions to methotrexate.

© 2004 The American College of Obstetricians and Gynecologists


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