“Bust enhancing” herbal products are widely advertised. No clinical trials have been published. These products contain a variety of ingredients, including grains, hops, saw palmetto, dong quai, chaste-tree berry, wild yam, kava, fennel, black cohosh, and fenugreek. Several of these herbs are hormonally active; for example, hops contain 8-prenylnaringenin, a phytoestrogen that is more potent than other dietary phytoestrogens. Many bust-enhancing dietary supplements contain substrates for Fusarium, a fungus that produces zearalenone, a potent estrogen that has been associated with breast enlargement in humans and other species. The use of bust-enhancing products should be discouraged because of lack of evidence for efficacy and long-term safety concerns.
There is no evidence that &#x201C;bust enhancing&#x201D; herbal products are effective, and safety concerns exist.
Department of Health Care Sciences, George Washington University School of Medicine, Washington, DC
Address reprint requests to: Adriane Fugh-Berman, MD, 1312 18th Street NW, Washington DC 20036; E-mail: firstname.lastname@example.org.
The author acknowledges Ed Kennelly, PhD, and Fredi Kronenberg, PhD, for high-pressure liquid chromatography analysis.
Received November 26, 2002. Received in revised form December 16, 2002. Accepted January 23, 2003.