Castleman disease is a lymphoreticular disorder, which may be clinically silent. However, systemic manifestations can occur, which include generalized adenopathy and life-threatening bronchiolitis obliterans.
A woman presented with vaginal mucosal lesions recalcitrant to initial treatment efforts. Progression of the disease required hospitalization for pulmonary involvement. Castleman disease was diagnosed after extensive multidisciplinary evaluation and excision of a pelvic mass. The patient's symptoms dramatically improved postoperatively.
Castleman disease should be included in the differential diagnosis in patients with paraneoplastic symptoms and a pelvic mass.
Recognition and surgical treatment of pelvic Castleman disease offer improvement for systemic manifestations, which may be mistaken for other benign conditions.
Section of Gynecologic Surgery, Mayo Clinic, Rochester, Minnesota
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Received August 10, 2001. Received in revised form February 19, 2002. Accepted March 14, 2002.