Obstetrics & Gynecology

Skip Navigation LinksHome > October 2002 - Volume 100 - Issue 4 > Leptin as an Acute Stress‐Related Hormone in the Fetoplacent...
Obstetrics & Gynecology:
Original Research

Leptin as an Acute Stress‐Related Hormone in the Fetoplacental Circulation

Takahashi, Yuichiro MD, PhD; Yokoyama, Yasuhiro MD, PhD; Kawabata, Ichiro MD, PhD; Iwasa, Shinichi MD, PhD; Tamaya, Teruhiko MD, PhD

Collapse Box


OBJECTIVE: To investigate the relationship between fetoplacental leptin secretion and blood gases.

METHODS: We measured the levels of umbilical arterial and venous leptin, umbilical cord gas, umbilical venous blood glucose, and estradiol‐17β (E2) in 89 pregnant women. Correlation between the leptin levels and other variables (gestational age, birth weight, maternal body weight, height, body mass index, maternal body weight gain, placental weight, umbilical cord gas data, and levels of umbilical venous blood glucose and E2) were examined statistically.

RESULTS: Umbilical arterial and venous leptin levels were 7.64 ± 12.76 and 7.76 ± 13.17 (ng/mL), respectively, correlating positively with carbon dioxide pressure levels (r = 0.446, P < .001; r = 0.406, P < .001, respectively) and correlating inversely with pH (r = −0.337, P = .001; r = −0.247, P = .019, respectively). Umbilical venous glucose, E2, and other factors did not correlate with leptin levels.

CONCLUSION: Leptin secretion into the fetoplacental circulation may be associated with fetal hypercapnia, suggesting two important roles for leptin: one for basal control of fetal fat tissue and one as an acute stress‐related hormone.

© 2002 by The American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved.



Looking for ABOG articles? Visit our ABOG MOC II collection. The selected Green Journal articles are free through the end of the calendar year.


If you are an ACOG Fellow and have not logged in or registered to Obstetrics & Gynecology, please follow these step-by-step instructions to access journal content with your member subscription.

Article Tools


Article Level Metrics