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The Effect of Pregnancy on Cyclosporine Levels in Renal Allograft Patients

THOMAS, ALBERT GEORGE MD; BURROWS, LEWIS MD; KNIGHT, RICHARD MD; PANICO, MARY RN; LAPINSKI, ROBERT PhD; LOCKWOOD, CHARLES J. MD
Obstetrics & Gynecology: December 1997
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Objective To assess the effects of pregnancy on cyclosporine levels in six renal allograft patients.

Methods Maternal demographic, laboratory, clinical, and perinatal outcome data were recorded in six pregnant women with previous renal allograft receiving cyclosporine immunosuppression. The cyclosporine and serum creatinine levels wee measured before pregnancy, during each trimester, and postpartum.

Results The mean (standard deviation [SD] maternal age was 29.1 (3.8) years. Parity from 0 to 3. Mean serum creatinine levels tended to be lower during pregnancy than before or after, as did the mean cyclosporine levels. After adjusting for dose, five of six patients had declines in cyclosporine level during pregnancy. The mean (SD) gestational age at delivery was 37.5 (2.8) weeks with a mean (SD) birth weight of 2837 (538) g.

Conclusion Pregnancy in patients with renal allografts can lead to a substantial decline in cycloporine levels.

Address reprint requests to: A. George Thomas, MD, Mount Sinai Medical Center, Department of Obstetrics and Gynecology, 1176 Fifth Avenue, Box 1170, New York, NY 10029

© 1997 The American College of Obstetricians and Gynecologists