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Calcium Supplementation in Mild Preeclampsia Remote From Term: A Randomized Double-Blind Clinical Trial

SANCHEZ-RAMOS, LUIS MD; ADAIR, C. DAVID MD; KAUNITZ, ANDREW M. MD; BRIONES, DONNA K. RNC, MS; DEL VALLE, GERARDO O. MD; DELKE, ISAAC MD
Obstetrics & Gynecology: June 1995
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Objective To determine whether calcium supplementation prevents progression to severe disease in preterm nulliparous women with mild preeclampsia.

Methods Seventy-five women hospitalized at 24–36 weeks' gestation because of mild preeclampsia were randomized to receive either 2 g/day of elemental calcium (36 women) or placebo (39). Both groups had similar demographic characteristics, initial blood pressure measurements, and amount of proteinuria. Diagnostic criteria and clinical management for severe preeclampsia were applied consistently.

Results Eighteen of 36 calcium-treated subjects (50%, 95% confidence interval [CI] 33–67) developed severe preeclampsia, compared with 19 of 39 (48.7%, 95% CI 32–65) in the placebo group (relative risk 1.03, 95% CI 0.64–1.03; P = 1.00). Blood pressure values, gestational age at delivery, newborn weights, incidence of low Apgar scores, and umbilical arterial blood gases were similar for the two groups.

Conclusion Calcium supplementation does not prevent severe preeclampsia in preterm patients with mild disease.

Address reprint requests to: Luis Sanchez-Ramos, MD, 653-1 West Eighth Street, Jacksonville, FL 32209-6561.

© 1995 The American College of Obstetricians and Gynecologists