Skip Navigation LinksHome > August 1994 - Volume 84 - Issue 2 > Vaginal Administration of Low-Dose Conjugated Estrogens: Sys...
Obstetrics & Gynecology:
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Vaginal Administration of Low-Dose Conjugated Estrogens: Systemic Absorption and Effects on the Endometrium.

HANDA, VICTORIA L. MD; BACHUS, KEVIN E. MD; JOHNSTON, WILLIAM W. MD; ROBBOY, STANLEY J. MD; HAMMOND, CHARLES B. MD

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Abstract

Objective: To test the hypothesis that a very-low-dose regimen of vaginal estrogen would provide effective relief from atrophic vaginitis without endometrial proliferation.

Methods: Twenty postmenopausal women with symptoms, signs, and cytologic evidence of atrophic vaginitis were enrolled. Each subject was treated with 0.3 mg of conjugated estrogens, administered vaginally 3 nights per week for 6 months. We examined the following outcomes: symptoms, vaginal cellular (cytologic) maturity, endometrial histology, sonographic evaluation of endometrial thickness, Doppler measures of uterine artery blood flow, and serum levels of estrone and estradiol. Pre- and posttreatment data were compared for each subject.

Results: Satisfactory relief of symptoms occurred in 19 of 20 cases. Vaginal cellular maturation improved significantly with therapy (P<.01). There were no significant changes in endometrial thickness, uterine artery blood flow, or serum estrogen levels. Endometrial proliferation was observed in one case.

Conclusion: Relief from atrophic vaginitis can be achieved with 0.3 mg of conjugated estrogens administered vaginally three times per week. Endometrial proliferation may occur at this low dose, albeit rarely.

(C) 1994 The American College of Obstetricians and Gynecologists

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