Home Articles & Issues Published Ahead-of-Print CME Collections ABOG MOC II Podcasts Videos Journal Info
Skip Navigation LinksHome > March 1982 - Volume 59 - Issue 3 > Clomiphene Citrate Therapy of Infertile Women with Low Lutea...
Obstetrics & Gynecology:
Original Article: PDF Only

Clomiphene Citrate Therapy of Infertile Women with Low Luteal Phase Progesterone Levels

HAMMOND, MARY G. MD; TALBERT, LUTHER M. MD

Collapse Box

Abstract

Sixty-nine infertile women with a midluteal serum progesterone level of 4 to 14 ng/ml were treated with a graduated dosage schedule of clomiphene citrate until the progesterone level on day 21 was greater than 20 ng/ml. Thirty-one pregnancies occurred, 58% during the first adequate treatment cycle and 19% during the second cycle. The abortion rate was 23%. After 6 adequate treatment cycles, laparoscopic evaluation was performed on 28 of 39 patients who did not conceive. Pathology was noted in 57%. Seven of 17 patients with intraperitoneal causes of infertility conceived after alternative therapy. The corrected pregnancy rate was 60%. Results of this study suggest that low luteal phase progesterone levels may compromise fertility and that clomiphene citrate enhances pregnancy rates.

(C) 1982 The American College of Obstetricians and Gynecologists

Login

Article Tools

Share