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CHEMOTHERAPY WITH THE MODIFIED BAGSHAWE PROTOCOL FOR POOR PROGNOSIS METASTATIC TROPHOBLASTIC DISEASE

Weed, John C. MD; Barnard, David E. MD; Currie, John L. MD; Clayton, Linda A. MD; Hammond, Charles B. MD
Obstetrics & Gynecology: March 1982
Instruments & Methods: PDF Only

The Southeastern Regional Trophoblastic Disease Center has treated 126 patients with metastatic gestational trophoblastic disease from 1966 through 1979. Sixty-three cases were categorized as having a poor prognosis on the basis of criteria published previously. Since 1976, 18 patients have been treated with a modification of Bagshawe's multiagent chemotherapy protocol. Ten of 18 patients (56%) have achieved sustained remission. Seventy-eight percent of these patients encountered serious myelosuppression (white blood count 1000 cells or fewer) and 39% suffered severe thrombocytopenia (platelet count 50,000 or fewer). There were no deaths related to drug toxicity. The courses of therapy and complications of modified Bagshawe chemotherapy are reviewed.

© 1982 The American College of Obstetricians and Gynecologists