Plasma Antithrombin III Activity in Normal Pregnancy.

WEINER, CARL P. MD; BRANDT, JOHN MD
Obstetrics & Gynecology: November 1980
Original Article: PDF Only

The incidence of thromboembolic phenomena increases in pregnancy. Antithrombin III has been implicated as a possible etiologic factor for the increase of thromboembolic phenomena in women receiving exogenous estrogens. In a study of normal obstetric, postpartum, and oral contraceptive patients, no significant change in antithrombin III activity could be detected in a plasma-based assay within and among these groups. It is hypothesized that a decrease in antithrombin III activity is not a cause of increased thromboembolic phenomena during normal pregnancy and oral contraceptive use.

(C) 1980 The American College of Obstetricians and Gynecologists