Twenty-one women were studied nhu had received propylthiouracil or methimuzole during 26 pregnancies. Four of the infants had a goiter at birth, and 3 of these had neonatal thyrotosicosis. In 2 children neonatal thyrotocicosis eas not evident at birth because of maternal antithyroid therapy. Five children had congenital defects. Two mothers nere responsible for 4 of the children with abnormalities, and both mothers had been treated with thiourea drugs for long periods, ranging from 7 to 11 years. The majority of children who are exposed to these drugs in utero appear to have no subsequent ill effects. However, prolonged therapy with these agents may be undesirable.
(C) 1975 The American College of Obstetricians and Gynecologists