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Treatment of Hyperthyroidism in Pregnancy Wit Propylthiouracil and Methimazole

MUJTABA, Q. MD; BURROW, G. N. MD
Obstetrics & Gynecology: September 1975
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Twenty-one women were studied nhu had received propylthiouracil or methimuzole during 26 pregnancies. Four of the infants had a goiter at birth, and 3 of these had neonatal thyrotosicosis. In 2 children neonatal thyrotocicosis eas not evident at birth because of maternal antithyroid therapy. Five children had congenital defects. Two mothers nere responsible for 4 of the children with abnormalities, and both mothers had been treated with thiourea drugs for long periods, ranging from 7 to 11 years. The majority of children who are exposed to these drugs in utero appear to have no subsequent ill effects. However, prolonged therapy with these agents may be undesirable.

© 1975 The American College of Obstetricians and Gynecologists