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Journal of Glaucoma:
doi: 10.1097/IJG.0b013e31829539f4
Online Articles: Case Reports

Late Acute Myopia Syndrome Induced by Combination of Sulfonamide Drugs

Kozner, Pavel MD, PhD*; Simonova, Katarina MD*; Brozek, Bretislav MD, PhD*; Singh, Kuldev MD, MPH

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Abstract

We present a case of late acute myopia syndrome following discontinuation of treatment with a combination of sulphonamide drugs. To the best of our knowledge, this is the first reported case with such a presentation, and suggests that the pathophysiological basis for the acute myopia syndrome is a rapid decrease in serum carbonic anhydrase inhibitors levels which may lead to a rebound increase in the production of aqueous humor and accumulation of suprachoroidal fluid. It is further postulated that there may be a cumulative effect of sulphonamide drug use on carbonic anhydrase activity in the ciliary body epithelium of susceptible individuals.

Copyright © 2013 by Lippincott Williams & Wilkins

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