We present a case of late acute myopia syndrome following discontinuation of treatment with a combination of sulphonamide drugs. To the best of our knowledge, this is the first reported case with such a presentation, and suggests that the pathophysiological basis for the acute myopia syndrome is a rapid decrease in serum carbonic anhydrase inhibitors levels which may lead to a rebound increase in the production of aqueous humor and accumulation of suprachoroidal fluid. It is further postulated that there may be a cumulative effect of sulphonamide drug use on carbonic anhydrase activity in the ciliary body epithelium of susceptible individuals.
*Department of Ophthalmology, Hospital Na Bulovce, Prague, Czech Republic
†Department of Opthalmology, Byers Eye Institute, Stanford University, Palo Alto, CA
Disclosure: The authors declare no conflict of interest.
Reprints: Pavel Kozner, MD, PhD, Department of Ophthalmology, Hospital Na Bulovce, Budinova 2, Prague 180 81, Czech Republic (e-mail: firstname.lastname@example.org).
Received October 16, 2012
Accepted March 12, 2013