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Determinants of Long-term Intraocular Pressure After Phacoemulsification in Primary Angle-closure Glaucoma

Liu, Catherine Jui-ling MD*,†; Cheng, Ching-Yu MD, PhD*,†,‡; Ko, Yu-Chieh MD*,†; Lau, Ling-Ing MD*,†,§

doi: 10.1097/IJG.0b013e3181efe1e9
Original Studies

Aims: To determine the preoperative factors associated with long-term intraocular pressure (IOP) after cataract surgery in primary angle-closure glaucoma (PACG).

Methods: The data of 56 PACG patients who had undergone phacoemulsification consecutively were analyzed after detailed chart review. The associations between postoperative IOP and various preoperative factors were determined by multivariate linear regression analyses.

Results: The mean postoperative follow-up was of 33.0±13.6 months. The postoperative IOP decreased (P<0.05 at each visit) from the preoperative level over the years, with a mean percent reduction of 20%. Glaucoma medication number also reduced significantly, except at month 30 (P=0.088), 36 (P=0.585), and 48 (P=0.104). Preoperative factors of higher IOP (P<0.001) and deeper anterior chamber depth (ACD) (P=0.006) were associated with higher postoperative IOP over the years. The multiplication product IOP×ACD accounted for 49% of the IOP variations 1 year after surgery, and eyes with this index less than or equal to 35 were more likely to achieve postoperative IOP readings of less than or equal to 12 mm Hg (odds ratio, 9.2, P=0.001) than those with an index more than 35.

Conclusions: Long-term IOP after phacoemulsification in PACG is positively associated with preoperative IOP and preoperative ACD.

*Department of Ophthalmology, Taipei Veterans General Hospital

National Yang Ming University School of Medicine

§Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD

Supported by a grant from Research Project No. V97A-045 of Taipei Veterans General Hospital, Taipei, Taiwan.

The funding organization had no role in the design or conduct of this research.

Disclosure: The authors declare no conflict of interest.

Reprints: Catherine Jui-ling Liu, MD, Department of Ophthalmology, Taipei Veterans General Hospital, No. 201, Shih-Pai Road, Section 2, Taipei, Taiwan 11217 (e-mail: jlliu@vghtpe.gov.tw).

Received February 23, 2010

Accepted June 27, 2010

© 2011 Lippincott Williams & Wilkins, Inc.