Journal of Glaucoma

Skip Navigation LinksHome > December 2011 - Volume 20 - Issue 9 > Axenfeld-Rieger Syndrome in Monozygotic Twins
Journal of Glaucoma:
doi: 10.1097/IJG.0b013e3181f7b258
Case Reports

Axenfeld-Rieger Syndrome in Monozygotic Twins

Ma, Jin MD*; Zhong, Yong MD*; Zhao, Chan MD*; Zhang, Xuejing MD; Sui, Ruifang MD*; Chu, Pinghao MD*; Zhao, Jialiang MD*

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Two teenaged monozygotic twin sisters with Axenfeld-Rieger syndrome (ARS) were referred to our center for uncontrolled glaucoma from the local hospital in December 2006. At presentation, typical components of ARS could be found in both patients, including iris anomaly, maxillary hypoplasia, hypodontia, and umbilical skin fold. Both sisters received trabeculectomy in both the eyes later in our center. Intraocular pressure was well controlled in both the eyes in both patients 1 year after the surgeries. No mutations were found by direct sequencing of PITX2 and FOXC1 genes, in the twin sisters. As far as we know, no earlier report has described monozygotic twins with ARS in the international literature.

© 2011 Lippincott Williams & Wilkins, Inc.


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