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Optic Nerve Head Morphology Assessed by Laser Scanning Tomography in Normal Japanese Subjects

Sawada, Yu MD, PhD; Ishikawa, Makoto MD, PhD; Sato, Noriko MD; Yoshitomi, Takeshi MD, PhD

doi: 10.1097/IJG.0b013e3181f3eb20
Original Studies

Purpose: To study the optic disc characteristics using the Heidelberg Retina Tomograph (HRT) II in normal Japanese subjects.

Methods: A total of 1060 eyes of 530 normal subjects with reliable HRT images, who participated in the community health checkup in the city of Akita, Japan, were included in the study. Optic disc parameters were obtained using the HRT II. Sex, age, height, weight, blood pressure, ocular perfusion pressure, hemoglobin A1c status, intraocular pressure, and disc area with HRT parameters were assessed using correlation and multiple regression analysis.

Results: Disc area and cup area averaged 2.04±0.44 mm2 (mean±standard deviation) and 0.51±0.34 mm2, respectively. There were no significant differences in parameters between right and left eyes. Males had significantly greater cup area, cup volume, cup/disc ratio than females (P<0.001) and smaller rim area and rim volume. Disc area was strongly correlated with all HRT parameters. Age had moderate correlations with several tomographic parameters in multiple regression analysis, whereas blood pressure, ocular perfusion pressure, intraocular pressure, hemoglobin A1c, height, and weight had weak or no correlations.

Conclusions: This study provided a range of normal HRT II optic disc parameters for Japanese subjects. Compared with data from studies on other races, the mean disc area and cup area of Japanese subjects were between that of African Americans and white subjects. Given the significant differences between males and females, a normative database of HRT II variables should be established by sex.

Department of Ophthalmology, Akita University School of Medicine, Akita, Japan

Supported by grant 30000020 from the National Health and Labor Science Research, Tokyo, Japan.

Disclosure: The authors declare no conflict of interest.

Reprints: Yu Sawada MD, PhD, Department of Ophthalmology, Akita University School of Medicine 1-1-1 Hondo Akita, 010-8543, Japan (e-mail: sawadayu@aol.com).

Received January 25, 2010

Accepted July 19, 2010

© 2011 Lippincott Williams & Wilkins, Inc.