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Adefovir combined with hepatitis C virus treatment may prevent hepatitis B reactivation after hepatitis C virus eradication in hepatitis B and C virus carriers

Renou, Christophea e; Cadranel, Jean-Françoisb; Pariente, Alexandrec; Pénaranda, Guillaumef; Bourlière, Marcd; Halfon, Philippeg; Igual, Jean-Pierrea; Harafa, Abdelouahida; Muller, Pierrea; Bertrand, Jean-Jacquesa; Laugier, Renée

European Journal of Gastroenterology & Hepatology: December 2008 - Volume 20 - Issue 12 - pp 1235-1237
doi: 10.1097/MEG.0b013e328305ba2a
Case Reports

This observation reports that a hepatitis B virus (HBV) reactivation, as the result of hepatitis C virus (HCV) eradication on a dominant HCV coinfected HBV/HCV patient, was subsequently prevented by treating both viral infections together. This finding raises the question as to whether preemptive HBV treatment should be prescribed along with HCV treatment to prevent HBV from being reactive after HCV eradication in coinfected HBV/HCV patients.

aGastroenterology Department, Hyères Hospital

bGastroenterology Department, Creil Hospital

cGastroenterology Department, Pau Hospital

dGastroenterology Department, Saint-Joseph Hospital

eGastroenterology Department, Timone Hospital

fBiostatistics Department, CDL Pharma

gVirology Department, Alphabio laboratory, Marseille, France

Correspondence to Christophe Renou, Gastroenterology Department, Hyères Hospital, BP 82, 83407 Hyères Cedex, France

Tel: +33 4 94 00 27 08; fax: +33 4 94 00 27 23;

e-mail: crenou@ch-hyeres.fr

Received 8 April 2008 Accepted 21 April 2008

© 2008 Lippincott Williams & Wilkins, Inc.