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Efficacy and tolerability of culture-guided treatment for Helicobacter pylori infection

Costa, Samuel; Soares, João-Bruno; Gonçalves, Raquel

European Journal of Gastroenterology & Hepatology: November 2017 - Volume 29 - Issue 11 - p 1258–1263
doi: 10.1097/MEG.0000000000000960
Original Articles: Gastro-esophageal Disorders

Objective: The aim of this study was to evaluate the efficacy/tolerability of a culture-guided approach in the eradication of Helicobacter pylori and identify factors associated with antibiotic resistance/treatment failure.

Patients and methods: This retrospective single-center study included patients who underwent culture-guided treatment for H. pylori infection, after two ineffective eradication attempts, between October 2012 and December 2016. We assessed the following demographic and clinical data of the patients: sex, age, BMI, alcohol and tobacco consumption, history of dyspepsia, peptic ulceration and first-degree relatives with gastric cancer, antibiotic susceptibility results, treatment composition, tolerability, and success. The treatment success was confirmed by a monoclonal stool antigen test.

Results: Culture-guided treatment was performed in 42 patients (57% women, mean age±SD: 48.9±11.4 years). The rates of antibiotic resistance were as follows: clarithromycin 86%, metronidazole 67%; levofloxacin 52%, tetracycline 2%, and amoxicillin and rifampicin 0%. Double resistance to clarithromycin and metronidazole was found in 59.5% of the patients. Most patients showed resistance to less than three antibiotics, but 31% were resistant to three or more. Intention-to-treat and per-protocol eradication rates were 59.5 and 61.5%. Adverse events occurred in 15 (35.7%) patients, but only two (4.8%) patients did not complete treatment because of adverse events. Only age more than 50 years was associated with resistance to three or more antibiotics. Having a first-degree relative with gastric cancer was associated with treatment failure and having a BMI of at least 25 kg/m2 protected from failure.

Conclusion: Third-line culture-guided treatment often fails to eradicate H. pylori infection. We need to find factors other than in-vitro antibiotic resistance to explain these suboptimal results.

Department of Gastroenterology, Hospital de Braga, Braga, Portugal

Correspondence to Samuel Costa, MD, Department of Gastroenterology, Hospital de Braga, Sete Fontes - São Victor, 4710-243 Braga, Portugal Tel: +351 967 643 117; fax: +351 253 027 999; e-mail: samuelcosta@hotmail.com

Received May 21, 2017

Accepted July 20, 2017

Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.