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Prevalence of hepatic steatosis in apparently healthy medical students: a transient elastography study on the basis of a controlled attenuation parameter

Kaya, Eda; Demir, Dogac; Alahdab, Yesim O.; Yilmaz, Yusuf

European Journal of Gastroenterology & Hepatology: November 2016 - Volume 28 - Issue 11 - p 1264–1267
doi: 10.1097/MEG.0000000000000681
Original Articles: Metabolic Liver Disease

Objective Despite the increasing burden of nonalcoholic fatty liver disease (NAFLD) in modern societies, the optimal screening method to detect hepatic steatosis in the general population remains to be established. Controlled attenuation parameter (CAP) measured with transient elastography (TE) has recently emerged as a reliable imaging tool for the screening and diagnosis of NAFLD. Here, we sought to investigate the prevalence of TE-defined hepatic steatosis in a sample of apparently healthy medical students. We also assessed the relationships between CAP and traditional NAFLD risk factors.

Materials and methods A total of 112 Turkish medical students (48 women and 64 men, mean age 20.5±1.1 years) underwent TE. On the basis of previous studies, a cut-off value of 238 dB/m for CAP was used for the diagnosis of hepatic steatosis.

Results On the basis of the selected cut-off for CAP, we identified 26 students (23.2%) with TE-defined NAFLD. Univariate correlation analyses showed that CAP values were significantly associated with BMI (r=0.40, P<0.001), waist circumference (r=0.39, P<0.001), and hip circumference (r=0.34, P<0.001). In multivariable analysis, only BMI retained its independent association with CAP (β=0.36, t=3.4, P<0.001).

Conclusion NAFLD is highly prevalent even in apparently healthy young individuals. CAP assessment with TE may be useful for an early, noninvasive identification of hepatic steatosis.

aSchool of Medicine

bDepartment of Gastroenterology, School of Medicine

cInstitute of Gastroenterology, Marmara University, Istanbul, Turkey

Correspondence to Yusuf Yilmaz, MD, Institute of Gastroenterology, Marmara University, Basibuyuk, Maltepe 34840, Istanbul, Turkey Tel: +90 533 4403995; fax: +90 216 4214002; e-mail: dryusufyilmaz@gmail.com

Received April 11, 2016

Accepted May 9, 2016

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