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European Journal of Gastroenterology & Hepatology:
doi: 10.1097/MEG.0000000000000150
Original Articles: Hepatitis

Delivery of treatment for hepatitis C virus infection in the primary care setting

Baker, Davida,b; Alavi, Maryamc; Erratt, Amandac; Hill, Sonjaa; Balcomb, Anniee; Hallinan, Richardd; Siriragavan, Sharmilac; Richmond, Davidf; Smart, Johng; Keats, Julianh; Doong, Nicholasi; Marks, Pipc; Grebely, Jasonc; Dore, Gregory J.c

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Abstract

Objectives

The aim of this study was to evaluate the feasibility, safety and efficacy of treatment for chronic hepatitis C virus (HCV) infection through a primary care-based model for the delivery of HCV services in New South Wales (NSW), Australia.

Participants and methods

This observational cohort study recruited participants through seven primary care clinics in NSW, Australia, between November 2010 and June 2013. Patients with HCV genotype 2/3 were treated without specialist review, whereas those with genotype 1 required an initial specialist review. Treatment consisted of pegylated interferon-α-2a/2b and ribavirin. Sustained virological response and adverse events were evaluated.

Results

Among 41 participants (mean age 44 years, 73% men) initiating treatment with pegylated interferon-α-2a/2b and ribavirin, 90% had injected drugs ever, 16% had injected drugs in the past 30 days and 56% had ever received opioid substitution treatment. HCV genotype 1 and genotype 2/3 occurred in 17% (n=7) and 83% (n=34). Treatment was completed in 83% (34 of 41), with seven discontinuations [adverse event (depression), n=1; patient decision, n=1; lost to follow-up, n=3; virological nonresponse, n=2]. In an intent-to-treat analysis, sustained virological response was 71% overall (29 of 41), 43% in genotype 1 (three of seven) and 76% in genotype 2/3 (26 of 34).

Conclusion

Initiation of HCV treatment in the primary care setting is an effective alternative for selected patients and may contribute towards increasing access to HCV care.

© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins

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