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European Journal of Gastroenterology & Hepatology:
doi: 10.1097/MEG.0000000000000132
Original Articles: Gastro-oesophageal Disease

Accuracy of GastroPanel for the diagnosis of atrophic gastritis

McNicholl, Adrian G.a,b; Forné, Montserratc; Barrio, Jesuse; De la Coba, Cristobalf; González, Begoñad; Rivera, Robing; Esteve, Mariab,c; Fernandez-Bañares, Fernandoc; Madrigal, Beatrize; Gras-Miralles, Beatrizd; Perez-Aisa, Angelesg; Viver-Pi-Sunyer, Jose M.c; Bory, Feliped; Rosinach, Mercec; Loras, Carmenb,c; Esteban, Carlosa; Santolaria, Santosh; Gomollon, Fernandob,i; Valle, Julioj; Gisbert, Javier P.a,b

Open Access
Erratum

Erratum

The authors would like to notify readers of an error in this article [1].

The serum levels of basal G17, PGI, PGII, and Hp-ab were measured using the GastroPanel-Biohit Oyj validated ELISA method, and not chemiluminescent enzyme immunoassay, as stated on page 942.

European Journal of Gastroenterology & Hepatology. 27(1):113, January 2015.

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Abstract

Background

It has been suggested that GastroPanel might be a useful tool for the diagnosis of chronic atrophic gastritis (CAG) measuring four biomarkers in blood: basal gastrin-17 (G17), pepsinogen I and II (PGI and PGII), and Helicobacter pylori antibodies.

Aim

To determine the accuracy of GastroPanel for the diagnosis of CAG.

Methods

This was a prospective, blinded, multicenter study that included dyspeptic patients. G17, PGI, and PGII were determined by enzyme immunoassays. Three antrum and two corpus biopsies were obtained for standard histological analysis and rapid urease test. Biopsies were analyzed by a single blinded expert pathologist.

Results

Ninety-one patients were included (77% women, mean age 44 years, 51% H. pylori positive, 17% with CAG). G17 was reduced in patients with antrum CAG (5.4 vs. 13.4 pmol/l; P<0.01) and increased in patients with corpus CAG (11 vs. 24 pmol/l; P<0.05), but its accuracy was only acceptable in the case of corpus localization [area under the receiver operating characteristic curve (AUC), 74%]; PGII difference was almost statistically significant only when testing for corpus atrophy (33 vs. 21 μg/l; P=0.05; AUC=72%). The PGI and PGI/PGII ratio showed no significant differences (AUCs were all unacceptably low). Helicobacter pylori antibody levels were higher in H. pylori-infected patients (251 vs. 109 EIU, P=0.01; AUC=70). The accuracy of GastroPanel for the diagnosis of CAG was as follows: sensitivity 50%; specificity 80%; positive 25% and negative 92% predictive values; and positive 2.4 and negative 0.6 likelihood ratios.

Conclusion

GastroPanel is not accurate enough for the diagnosis of CAG; thus, its systematic use in clinical practice cannot be recommended.

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.
http://creativecommons.org/licenses/by-nc-nd/3.0.

© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins

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