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European Journal of Gastroenterology & Hepatology:
doi: 10.1097/MEG.0b013e3283613139
Original Articles: Hepatitis

Diagnostic accuracy of hepatic venous pressure gradient measurement in the prediction of stage 1 compensated liver cirrhosis in patients with chronic hepatitis B.

Suk, Ki Taea; Kim, Heung Cheolb; Namkung, Sookb; Han, Sang Hakc; Choi, Kyung Chanc; Park, Seung Hae; Sung, Ho Taikg; Kim, Chang Hoonh; Kim, Seong Hoona; Ham, Young Limf; Kang, Hee Mod; Kim, Dong Joona

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Abstract

Objective

Hepatic venous pressure gradient (HVPG) of 6–10 mmHg has been accepted as a hemodynamic parameter of stage 1 compensated liver cirrhosis (LC). The diagnostic accuracy of HVPG in the prediction of stage 1 compensated LC has been investigated in patients with chronic hepatitis B (CHB).

Methods

A total of 219 patients with CHB who underwent HVPG and liver biopsy were enrolled. The diagnostic accuracy of two methods was compared. Risk factors associated with the diagnosis of stage 1 compensated LC on the basis of the findings of HVPG, biopsy, and both HVPG and biopsy were evaluated.

Results

The HVPG score was correlated positively with the stage of biopsy (r=0.439). The sensitivity/specificity of HVPG for predicting stage 1 compensated LC were 78/81% in 6 mmHg, respectively. A total of 57 (26%), 28 (13%), and 20 (9%) patients were diagnosed with stage 1 compensated LC on the basis of the findings of HVPG, biopsy, and both HVPG and biopsy (P>0.05), respectively. Platelet/age (−0.77–0.01×platelet+0.03×age), albumin/platelet (5.05−1.19×albumin−0.01×platelet), and platelet (0.24−0.01×platelet) were found to be risk factors (logit model) for the diagnosis of stage 1 compensated LC on the basis of the findings of HVPG, biopsy, and both HVPG and biopsy.

Conclusion

HVPG showed a positive correlation with biopsy, and platelet was found to be a common risk factor for the diagnosis of stage 1 compensated LC in patients with CHB.

© 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins

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