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European Journal of Gastroenterology & Hepatology:
doi: 10.1097/MEG.0b013e3283613139
Original Articles: Hepatitis

Diagnostic accuracy of hepatic venous pressure gradient measurement in the prediction of stage 1 compensated liver cirrhosis in patients with chronic hepatitis B

Suk, Ki Taea; Kim, Heung Cheolb; Namkung, Sookb; Han, Sang Hakc; Choi, Kyung Chanc; Park, Seung Hae; Sung, Ho Taikg; Kim, Chang Hoonh; Kim, Seong Hoona; Ham, Young Limf; Kang, Hee Mod; Kim, Dong Joona

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Abstract

Objective: Hepatic venous pressure gradient (HVPG) of 6–10 mmHg has been accepted as a hemodynamic parameter of stage 1 compensated liver cirrhosis (LC). The diagnostic accuracy of HVPG in the prediction of stage 1 compensated LC has been investigated in patients with chronic hepatitis B (CHB).

Methods: A total of 219 patients with CHB who underwent HVPG and liver biopsy were enrolled. The diagnostic accuracy of two methods was compared. Risk factors associated with the diagnosis of stage 1 compensated LC on the basis of the findings of HVPG, biopsy, and both HVPG and biopsy were evaluated.

Results: The HVPG score was correlated positively with the stage of biopsy (r=0.439). The sensitivity/specificity of HVPG for predicting stage 1 compensated LC were 78/81% in 6 mmHg, respectively. A total of 57 (26%), 28 (13%), and 20 (9%) patients were diagnosed with stage 1 compensated LC on the basis of the findings of HVPG, biopsy, and both HVPG and biopsy (P>0.05), respectively. Platelet/age (−0.77–0.01×platelet+0.03×age), albumin/platelet (5.05−1.19×albumin−0.01×platelet), and platelet (0.24−0.01×platelet) were found to be risk factors (logit model) for the diagnosis of stage 1 compensated LC on the basis of the findings of HVPG, biopsy, and both HVPG and biopsy.

Conclusion: HVPG showed a positive correlation with biopsy, and platelet was found to be a common risk factor for the diagnosis of stage 1 compensated LC in patients with CHB.

© 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins

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