Skip Navigation LinksHome > June 2008 - Volume 15 - Issue 3 > The incidence of contrast-induced nephropathy in trauma pati...
European Journal of Emergency Medicine:
doi: 10.1097/MEJ.0b013e328270367d
Original Articles

The incidence of contrast-induced nephropathy in trauma patients

Hipp, Antonia; Desai, Shoma; Lopez, Carmen; Sinert, Rich

Collapse Box


Background: We measured the incidence and risk factors for contrast-induced nephropathy (CIN) in trauma patients.

Methods: We conducted a retrospective review of a prospectively collected trauma database. We studied injured patients who received a contrast-enhanced computer tomography with an initial and repeat serum creatinine after 48 h. Exclusion criteria were patients on dialysis. CIN was defined as a 25% rise in creatinine or an increase in creatinine ≥0.5 mg/dl from baseline 48 h after contrast. Data were reported as means±SD. Group comparisons were made by Fisher's exact test or Student's t-test (α=0.05, two tails).

Results: In total, 235 patients were studied with an average age of 44±20 (13–92 years) (80% men), 79% of whom had blunt injuries. CIN incidence was 5.1% [95% confidence interval (CI), 2.9–8.8%]. No patients in the CIN or non-CIN groups died, or required in-patient/chronic dialysis. CIN patients were significantly (P=0.003) older (61 vs. 43 years). For age ≥75 years, the relative risk was 7.7 and the number needed to harm was 5. An elevated creatinine (more than 1.5 mg/dl) was significantly (P=0.007) associated with CIN. For creatinine greater than 1.5 mg/dl, the relative risk was 6.4 and the number needed to harm was 6. CIN was significantly (P=0.02) more likely in patients with glomerular filtration rate less than 60 ml/min/1.73 m2. We found no significant (P>0.05) difference in base-deficit, lactate, and Injury Severity Score between CIN and non-CIN patients.

Conclusion: We found a 5.1% incidence of CIN in trauma patients exposed to intravenous contrast. Elderly and trauma patients with low glomerular filtration rate were especially predisposed to CIN.

© 2008 Lippincott Williams & Wilkins, Inc.


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.