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Association of body mass index and risk of death from pancreas cancer in Asians: findings from the Asia Cohort Consortium

Lin, Yingsonga; Fu, Rongi; Grant, Ericb; Chen, Yuj; Lee, Jung Euns; Gupta, Prakash C.x; Ramadas, Kunnambathy; Inoue, Manamid; Tsugane, Shoichirod; Gao, Yu-Tangz; Tamakoshi, Akikoe; Shu, Xiao-Oun; Ozasa, Kotarob; Tsuji, Ichirof; Kakizaki, Masakof; Tanaka, Hideoh; Chen, Chien-JenI,II; Yoo, Keun-Youngt; Ahn, Yoon-Okt; Ahsan, Habibulo,p,q,r; Pednekar, Mangesh S.x; Sauvaget, CatherineIV; Sasazuki, Shizukad; Yang, Gongn; Xiang, Yong-Bingz; Ohishi, Wakac; Watanabe, Takashif; Nishino, Yoshikazug; Matsuo, Keitaroh; You, San-LinI,III; Park, Sue K.t,u,v; Kim, Dong-Hyunw; Parvez, Faruquek; Rolland, Betsyi; McLerran, Dalei; Sinha, Rashmim; Boffetta, Paolol,V; Zheng, Wein; Thornquist, Marki; Feng, Zidingi; Kang, Daeheet; Potter, John D.i,V

European Journal of Cancer Prevention: May 2013 - Volume 22 - Issue 3 - p 244–250
doi: 10.1097/CEJ.0b013e3283592cef
Research Papers: Gastrointestinal Cancer

We aimed to examine the association between BMI and the risk of death from pancreas cancer in a pooled analysis of data from the Asia Cohort Consortium. The data for this pooled analysis included 883 529 men and women from 16 cohort studies in Asian countries. Cox proportional-hazards models were used to estimate the hazard ratios and 95% confidence intervals for pancreas cancer mortality in relation to BMI. Seven predefined BMI categories (<18.5, 18.5–19.9, 20.0–22.4, 22.5–24.9, 25.0–27.4, 27.5–29.9, ≥30) were used in the analysis, with BMI of 22.5–24.9 serving as the reference group. The multivariable analyses were adjusted for known risk factors, including age, smoking, and a history of diabetes. We found no statistically significant overall association between each BMI category and the risk of death from pancreas cancer in all Asians, and obesity was unrelated to the risk of mortality in both East Asians and South Asians. Age, smoking, and a history of diabetes did not modify the association between BMI and the risk of death from pancreas cancer. In planned subgroup analyses among East Asians, an increased risk of death from pancreas cancer among those with a BMI less than 18.5 was observed for individuals with a history of diabetes; hazard ratio=2.01 (95% confidence interval: 1.01–4.00) (P for interaction=0.07). The data do not support an association between BMI and the risk of death from pancreas cancer in these Asian populations.

aDepartment of Public Health, Aichi Medical University School of Medicine, Nagakute

Departments of bEpidemiology

cClinical Studies, Radiation Effects Research Foundation, Hiroshima

dEpidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo

eDepartment of Public Health, Hokkaido University Graduate School of Medicine, Sapporo

fDivision of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine

gDivision of Cancer Epidemiology and Prevention, Miyagi Cancer Center Research Institute, Miyagi

hDivision of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan

iDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington

jDepartment of Environmental Medicine, New York University School of Medicine

kDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University

lThe Tisch Cancer Institute and Institute for Translational Epidemiology, Mount Sinai School of Medicine, New York

mDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland

nDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee

Departments of oHealth Studies

pMedicine

qHuman Genetics

rComprehensive Cancer Center, The University of Chicago, Chicago, Illinois, USA

sDepartment of Food and Nutrition, Sookmyung Women’s University

tDepartment of Preventive Medicine, Seoul National University College of Medicine

uCancer Research Institute, Seoul National University

vDepartment of Biomedical Science, Seoul National University Graduate School, Seoul

wDepartment of Social and Preventive Medicine, Hallym University College of Medicine, Chuncheon, Korea

xHealis-Sekhsaria Institute for Public Health, Navi Mumbai

yDivision of Radiation Oncology, Regional Cancer Center, Medical College Campus, Trivandrum, India

zDepartment of Epidemiology, Shanghai Cancer Institute, Shanghai, China

IGenomics Research Center, Academia Sinica

IIGraduate Institute of Epidemiology, College of Public Health, National Taiwan University

IIISchool of Public Health, National Defense Medical Center, Taipei, Taiwan

IVScreening Group, International Agency for Research on Cancer

International Prevention Research Institute, Lyon, France

VCentre for Public Health Research, Massey University, Wellington, New Zealand

Correspondence to Yingsong Lin, MD, PhD, Department of Public Health, Aichi Medical University School of Medicine, 1-1 Yazokokarimata, Nagakute, Aichi 480 1195, Japan Tel: +81 561 62 3311; fax: +81 561 62 5270; e-mail: linys@aichi-med-u.ac.jp

Received July 27, 2012

Accepted July 29, 2012

© 2013 Lippincott Williams & Wilkins, Inc.