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Human breast tumor slices as an alternative approach to cell lines to individualize research for each patient

Conde, Sandro José; Luvizotto, Renata de Azevedo Melo; de Síbio, Maria Teresa; Nogueira, Célia Regina

European Journal of Cancer Prevention:
doi: 10.1097/CEJ.0b013e32834dbc42
Short Paper: Breast Cancer

There are several breast cancer experimental models including cell lines, which are commonly used due to ease of handling and storage. However, the continued propagation of cell lines and distribution among laboratories results in genetic drift and distancing from the in-vivo model. Primary organ culture of breast cancer slices may produce biological responses with high standard deviation for different samples, reflecting the heterogeneity of different tumors. Thus, the organ culture model system offers a new perspective to the results obtained in the cell lines and offers an alternative for studies that seek to individualize treatment for each patient, an increasingly prominent concern in current cancer therapy.

Author Information

Department of Medical Clinic, Division of Endocrinology and Metabolism, UNESP, Botucatu, Brazil

Correspondence to Célia Regina Nogueira, Department of Medical Clinic, Division of Endocrinology and Metabolism, UNESP, Distrito de Rubião Junior s/n, CEP: 18618-000 Botucatu, SP, Brazil Tel: +55 14 38116213; fax: +55 14 38116424; e-mail:

Received August 15, 2011

Accepted September 20, 2011

© 2012 Lippincott Williams & Wilkins, Inc.