Skip Navigation LinksHome > July 2012 - Volume 21 - Issue 4 > Alcohol consumption and prostate cancer risk: a meta-analys...
European Journal of Cancer Prevention:
doi: 10.1097/CEJ.0b013e32834dbc11
Review Article: Prostate Cancer

Alcohol consumption and prostate cancer risk: a meta-analysis of the dose–risk relation

Rota, Matteoa,b; Scotti, Lorenzab; Turati, Federicac,d; Tramacere, Irenec; Islami, Farhadf,h,i; Bellocco, Rinob,j; Negri, Evac; Corrao, Giovannib; Boffetta, Paolog,i; La Vecchia, Carloc,d; Bagnardi, Vincenzob,e

Supplemental Author Material
Collapse Box

Abstract

Inconsistent results on the relationship between alcohol drinking and prostate cancer have been found. In order to provide a definite quantification of the dose–risk relation, we investigated the risk of prostate cancer at different levels of alcohol consumption, by conducting a meta-analysis of epidemiological studies. We performed a literature search using PubMed of all case–control and cohort studies published as original articles in English up to December 2010. We identified 50 case–control and 22 cohort studies, including a total of 52 899 prostate cancer cases. We derived pooled meta-analytic estimates using random-effects models, taking into account the correlation between estimates. We performed a dose–risk analysis using nonlinear random-effects meta-regression models. The overall relative risk for any alcohol drinking compared with non/occasional drinking was 1.06 [95% confidence interval (CI), 1.01–1.10]. The relative risks were 1.05 (95% CI, 1.02–1.08), 1.06 (95% CI, 1.01–1.11), and 1.08 (95% CI, 0.97–1.20) for light (≤1 drink/day), moderate (>1 to <4 drinks/day), and heavy alcohol drinking (≥4 drinks/day), respectively. This comprehensive meta-analysis provided no evidence of a material association between alcohol drinking and prostate cancer, even at high doses.

© 2012 Lippincott Williams & Wilkins, Inc.

Login

Article Tools

Share

Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.