Skip Navigation LinksHome > May 2012 - Volume 21 - Issue 3 > Seaweed consumption and the risk of thyroid cancer in women:...
European Journal of Cancer Prevention:
doi: 10.1097/CEJ.0b013e32834a8042
Research Papers: Thyroid cancer

Seaweed consumption and the risk of thyroid cancer in women: the Japan Public Health Center-based Prospective Study

Michikawa, Takehiroa,b; Inoue, Manamia; Shimazu, Taichia; Sawada, Noriea; Iwasaki, Motokia; Sasazuki, Shizukaa; Yamaji, Taikia; Tsugane, Shoichiroa; for the Japan Public Health Center-based Prospective Study Group

Collapse Box

Abstract

Iodine is a suspected risk factor for thyroid cancer. Seaweed accounts for about 80% of Japanese people’s iodine intake. We examined the association between seaweed consumption and the risk of thyroid cancer in Japanese women. Women participating in the Japan Public Health Center-based Prospective Study (n=52 679; age: 40–69 years) were followed up for a mean of 14.5 years; 134 new thyroid cancer cases, including 113 papillary carcinoma cases, were identified. Seaweed consumption was assessed using a food-frequency questionnaire and divided into three categories: 2 days/week or less (reference); 3–4 days/week; and almost daily. The Cox proportional hazards model was applied to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Seaweed consumption was clearly associated with an increased risk of papillary carcinoma (HR for almost daily consumption compared with 2 days/week or less=1.71; 95% CI: 1.01–2.90; trend P=0.04). After stratification for menopausal status, an increased risk was observed in postmenopausal women (papillary carcinoma HR for almost daily consumption compared with 2 days/week or less=3.81, 95% CI: 1.67–8.68; trend P<0.01), but not in premenopausal women (HR=0.91, 95% CI: 0.44–1.91; trend P=0.76). This study identified a positive association between seaweed consumption and the risk of thyroid cancer (especially for papillary carcinoma) in postmenopausal women.

© 2012 Lippincott Williams & Wilkins, Inc.

Login

Article Tools

Share

Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.