Skip Navigation LinksHome > May 2012 - Volume 21 - Issue 3 > High hepatitis B virus infection in B-cell lymphoma tissue a...
European Journal of Cancer Prevention:
doi: 10.1097/CEJ.0b013e3283498e87
Research Papers: Hematological cancer

High hepatitis B virus infection in B-cell lymphoma tissue and its potential clinical relevance

Wang, Fenga,d*; Yuan, Shuqiangb*; Teng, Kai-yuana,d; Garcia-Prieto, Celiae; Luo, Hui-yana,d; Zeng, Mu-shengd; Rao, Hui-lanc,d; Xia, Yia,d; Jiang, Wen-qia,d; Huang, Hui-qianga,d; Xia, Zhong-juna,d; Sun, Xiao-feia,d; Xu, Rui-huaa,d

Collapse Box


Our previous studies found that patients with B-cell non-Hodgkin lymphoma (NHL) had a higher incidence of hepatitis B virus (HBV) infection in serum than patients with T-cell NHL or other cancers. We sought to identify a possible role of HBV infection in B-cell NHL tumorigenesis and to understand its underlying clinical relevance. Fresh and paraffin-embedded primary tumor tissue from patients with NHL as well as from those with other lymphatic system diseases were investigated by PCR and immunohistochemistry. Many more patients with B-cell lymphoma whose serum was positive for hepatitis B surface antigen (HBsAg) were also positive for HBV-DNA than were those with T-cell NHL or other lymphatic system diseases whose serum was positive for HBsAg, in both fresh (55 vs. 15.4%) and paraffin-embedded (38.3 vs. 11.8%) tissue. Positive expression of the HBV-associated proteins HBsAg and hepatitis B core antigen was found in B-cell NHL lymphocytes and endothelial cells. Only 8.3% of patients with B-cell NHL who were negative for HBsAg but positive for other HBV markers were positive for HBV-DNA in tumor tissue. These results suggest that chronic HBV infection in lymph nodes could be associated with B-cell lymphoma.

© 2012 Lippincott Williams & Wilkins, Inc.


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.