Enter your Email address:
Wolters Kluwer Health may email you for journal alerts and information, but is committed
to maintaining your privacy and will not share your personal information without
You currently have no recent searches
Hsieh, Chia-Chen; Liu, Te-Yu; Chiu, Yu-Wen; Chuang, Hung-Yi
Kaohsiung Medical University, Kaohsiung City, Taiwan.
To investigate the effects of blood lead and other related factors on δ-aminolevulinic acid dehydratase (ALAD) activity in lead workers.
In 121 lead workers and 117 reference subjects, the following data were collected from health examination: blood lead, BMI, glucose AC, and Hct. A questionnaire including demographic data, medical history, smoking and alcohol consumption was completed by each of subjects. ALAD activity was determined by the standardized method of the European Community. ALAD polymorphism genotyping was using a method of PCR-RFLP.
In this study, 229 ALAD1-1 homozygotes (96.2%), 8 ALAD1-2 heterozygotes (3.8%) were identified, and none of ALAD2-2 homozygote was observed. Blood lead levels in lead workers and reference subjects were 19.5 μg/dL (SD = 14.7) and 2.9 μg/dL (SD = 1.9), respectively. Lead workers had significantly lower ALAD activity than reference subjects (42.6 ± 22.4 U/L vs. 64.3 ± 13.8 U/L, P < 0.001). According to the multiple regression results, the following independent variables were significant related to ALAD activity: ALAD activity in females was much lower (8.15 U/L) than males (P < 0.001); blood lead and glucose AC were inversely associated with ALAD activity (P < 0.001), but the effect of blood lead was profound. The regression coefficients of blood lead and glucose AC were 1.04 and 0.11, respectively. Individuals with alcohol consumption showed lower ALAD activity (P = 0.049). The possible threshold value of blood lead for ALAD activity was determined at around 10 μg/dL.
ALAD activity was inhibited by lead sensitively and stoichiometrically, thus ALAD activity may be adopted as a reliable biomarker of lead toxicity in humans.
© 2009 Lippincott Williams & Wilkins, Inc.
Colleague's E-mail is Invalid
Your Name: (optional)
Separate multiple e-mails with a (;).
Thought you might appreciate this item(s) I saw at Epidemiology.
Send a copy to your email
Your message has been successfully sent to your colleague.
Some error has occurred while processing your request. Please try after some time.
An Existing Folder
A New Folder
The item(s) has been successfully added to "".
Login with your LWW Journals username and password.
Username or Email:
Enter and submit the email address you registered with. An email with instructions to reset your password will be sent to that address.
Link to reset your password has been sent to specified email address.
What does "Remember me" mean?
By checking this box, you'll stay logged in for
days or until you logout. You'll get easier access to your articles, collections,
media, and all your other content, even if you close your browser or shut down your
To protect your most sensitive data and activities (like changing your password),
we'll ask you to re-enter your password when you access these services.
What if I'm on a computer that I share with others?
If you're using a public computer or you share this computer with others, we recommend
that you uncheck the "Remember me" box.
Save my selection