Enter your Email address:
Wolters Kluwer Health may email you for journal alerts and information, but is committed
to maintaining your privacy and will not share your personal information without
Wilker, Elissa*; Baccarelli, Andrea*†; Suh, Helen*; Vokonas, Pantel§; Wright, Robert*‡; Schwartz, Joel*‡
*Harvard School of Public Health, Boston, MA, United States; †University of Milan & IRCCS OMPMaRE Foundation, Milan, Italy; ‡Channing Laboratory, Boston, United States; and §VA Medical Center, Boston, MA, United States.
Evidence suggests that black carbon (BC) from traffic pollution contributes significantly to particle-related cardiovascular effects but the underlying mechanisms are unclear. Micro-RNAs (miRNAs) are small non-coding RNAs involved in processes related to angiogenesis, inflammation, and endothelial cell function. However, whether miRNAs mediate cardiovascular effects of particulate has not been examined. We hypothesized that associations between BC and systolic and diastolic blood pressure (SBP and DBP) would be modified by single nucleotide polymorphisms (SNPs) in genes related to miRNA processing.
We used mixed models with random intercepts and adjusted for potential confounders to examine longitudinal associations between BC and BP. Effect modification was assessed by 38 miRNA-related SNPs using dominant models of inheritance.
704 participants provided blood pressure measurements and DNA. Significant interactions with BC predicting both SBP and DBP were observed for rs1834306 in mir100. For example, a 1 SD increase in BC for rs1834306 was associated with 4.2% higher SBP (95% CI: 2.8, 5.5) in wild-type individuals and 2.1% higher SBP (95% CI: 1.3, 2.9) in subjects with the variant. BC was associated with 5.0% higher DBP (95% CI: 3.7, 6.4) and a 3.0% higher DBP (95% CI: 2.3, 3.8) respectively. For SBP models, interactions were also observed for SNPs in GEMIN4, RAN, and AGO1, while in DBP models, we observed interactions with SNPs in GEMIN3, and additional SNPs in GEMIN4. These associations remained significant after adjustment for multiple testing.
We observed independent associations between BP and BC and found that this association may be modified by SNPs related to miRNA processing. Interestingly, effects were particularly strong with SNPs in GEMIN4, which essential to pre-mRNA splicing and assembly of ribonucleoproteins.
© 2009 Lippincott Williams & Wilkins, Inc.
Colleague's E-mail is Invalid
Your Name: (optional)
Separate multiple e-mails with a (;).
Thought you might appreciate this item(s) I saw at Epidemiology.
Send a copy to your email
Your message has been successfully sent to your colleague.
Some error has occurred while processing your request. Please try after some time.
An Existing Folder
A New Folder
The item(s) has been successfully added to "".
Login with your LWW Journals username and password.
Username or Email:
Enter and submit the email address you registered with. An email with instructions to reset your password will be sent to that address.
Link to reset your password has been sent to specified email address.
What does "Remember me" mean?
By checking this box, you'll stay logged in until you logout. You'll get easier access to your articles, collections,
media, and all your other content, even if you close your browser or shut down your
To protect your most sensitive data and activities (like changing your password),
we'll ask you to re-enter your password when you access these services.
What if I'm on a computer that I share with others?
If you're using a public computer or you share this computer with others, we recommend
that you uncheck the "Remember me" box.
Save my selection
Article Level Metrics