Enter your Email address:
Wolters Kluwer Health may email you for journal alerts and information, but is committed
to maintaining your privacy and will not share your personal information without
You currently have no recent searches
Strumylaite, Loreta*; Bogusevicius, Algirdas†; Abdrakhmanov, Oleg*; Baranauskiene, Dale*; Kregzdyte, Rima*; Pranys, Darius‡; Poskiene, Lina‡
*Institute For Biomedical Research Kaunas University of Medicine, Kaunas, Lithuania; †Department of Surgery Kaunas University of Medicine, Kaunas, Lithuania; and ‡Department of Pathological Anatomy Kaunas University of Medicine, Kaunas, Lithuania.
Cadmium is a known human carcinogen based on findings of lung cancer in exposed populations. A more controversial target site for cadmium is the human mammary gland, for which some studies indicate a link between cadmium exposure and cancer. Some authors suggest that cadmium is a new environmental estrogen that mimics the effects of estradiol in estrogen-responsive breast cancer cell lines. In order to assess an association of cadmium with human breast cancer, we examined cadmium concentration in urine and breast tissue of patients with breast cancer and non-malignant breast tumour.
Cadmium was analyzed in the samples of urine and breast tissue of 57 breast cancer patients and 50 benign tumour patients. Two samples of breast tissue from each patient, i.e. tumour and some healthy tissue close to tumour were taken for the analysis. Cadmium was determined by atomic absorption spectrometry (Perkin-Elmer, Zeeman 3030). Estrogen receptors (ER) determined by immunohistochemical assay.
The mean cadmium concentration in breast cancer patients was 53.4 ng/g (95% CI = 42.2–64.6) for tumour sample and 20.1 ng/g (95% CI = 14.4–25.9) for healthy breast tissue sample (P < 0.001). In benign tumour patients the figures were following: 37.2 ng/g (95% CI = 23.3–51.1) and 32.1 ng/g (95% CI = 17.5–46.5) (P = 0.449). Cadmium concentration found in the sample of malignant tumour differed significantly from that in the sample of benign tumour (P < 0.001). Significantly higher concentration of cadmium determined in breast cancer patients with positive ER compare to that with negative ER (67.5 ng/g 95% CI = 48.7–86.2 vs. 42.5 ng/g 95% CI = 28.6–56.4, P = 0.035). There was a positive correlation between cadmium in the samples of breast tumour and urine (R = 0.3, P = 0.01). In breast cancer patients cadmium in urine correlated with number of cigarettes smoked during lifetime (R = 0.7, P = 0.02).
The data obtained show a possible relationship between cadmium and breast cancer.
© 2009 Lippincott Williams & Wilkins, Inc.
Colleague's E-mail is Invalid
Your Name: (optional)
Separate multiple e-mails with a (;).
Thought you might appreciate this item(s) I saw at Epidemiology.
Send a copy to your email
Your message has been successfully sent to your colleague.
Some error has occurred while processing your request. Please try after some time.
An Existing Folder
A New Folder
The item(s) has been successfully added to "".
Login with your LWW Journals username and password.
Username or Email:
Enter and submit the email address you registered with. An email with instructions to reset your password will be sent to that address.
Link to reset your password has been sent to specified email address.
What does "Remember me" mean?
By checking this box, you'll stay logged in until you logout. You'll get easier access to your articles, collections,
media, and all your other content, even if you close your browser or shut down your
To protect your most sensitive data and activities (like changing your password),
we'll ask you to re-enter your password when you access these services.
What if I'm on a computer that I share with others?
If you're using a public computer or you share this computer with others, we recommend
that you uncheck the "Remember me" box.
Save my selection