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Epidemiology:
doi: 10.1097/01.ede.0000362835.29709.96
Abstracts: ISEE 21st Annual Conference, Dublin, Ireland, August 25-29, 2009: Symposium Abstracts: Symposia Presentations

Acute Effect of Black Carbon and Particle Pollution in the Air on Exhaled Nitric Oxide of Elementary School Children Before and During 2008 Beijing Olympic

Lin, Weiwei; Zhu, Tong; Huang, Wei; Hu, Min; Chen, Hong; Zhang, Yuanhang; Liu, Xingang; Li, Chengcai; Tang, Xiaoyan

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College of Environmental Sciences and Engineering, Peking University, Beijing, China.

Abstracts published in Epidemiology have been reviewed by the organizations of Epidemiology. Affliate Societies at whose meetings the abstracts have been accepted for presentation. These abstracts have not undergone review by the Editorial Board of Epidemiology.

ISEE-0656

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Background:

Before and during 2008 Beijing Olympics, extensive control measures were taken to drastically improve the air quality during the Olympics. This provided an excellent opportunity for studies on health effects of air pollution.

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Methods:

A panel of 37 9–12 year old school children in Beijing was studied to evaluate the associations between the exposure of black carbon and particulate matter with exhaled nitric oxide (eNO). The concentrations of PM2.5, black carbon in PM2.5 (BC) and in total suspended particle (TBC), as well as gaseous pollutants were measured on a daily basis. We analyzed the correlation between eNO and ambient pollutants with generalized estimating equations (GEE) and polynomial distributed lag models (PDL), controlling for weight, asthma state, ambient temperature and relative humidity.

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Preliminary Results:

Significant associations were found between eNO increase and exposures to ambient pollution. The strongest positive associations were found between eNO and 48-hr average pollutant concentrations. In response to a 1 μg/m3 increase of BC for 24hr (lag0), 25hr–48hr (lag1) and 48hr, eNO increased 3.9% (95% CI, 3.3–4.5%), 2.2% (95% CI, 1.6–2.9%), and 4.6% (95% CI, 3.9–5.4%) respectively. For TBC, the eNO increased 2.4% (95% CI, 2.1–2.8%), 1.5% (95% CI, 1.1–1.9%) and 2.9% (95% CI, 2.4–3.3%), respectively. For PM2.5, the eNO increased 2.9% (95% CI, 2.4–3.5%) 0.8% (95% CI, 0.2–1.3%) and 3.2% (95% CI, 2.5–3.9%), respectively. We found that eNO was associated with hourly averages of BC and TBC up to 10–14 hr after exposure. The sum for the lag coefficients covering 48 hours was 4.10% eNO per 1 μg/m3 increase in BC.

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Conclusions:

This study provides evidence of the health benefits of air pollution control measures for the Beijing Olympics, as well as new evidence on the health effects of black carbon on inflammation biomarkers, and the lag effect structure between black carbon exposure and respiratory health parameters.

© 2009 Lippincott Williams & Wilkins, Inc.

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