ISEE 2007 CONFERENCE ABSTRACTS SUPPLEMENT: Abstracts
Overweight and obesity are major public health concerns worldwide. It has been hypothesized that in utero exposure to endocrine disrupting chemicals, such as DDT, may play a role in the etiology of obesity. The Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) study is a longitudinal birth cohort study of low-income Latinas living in an agricultural community in California. We examined the relation of in utero DDT and DDE exposure with prevalence of overweight at 24, 42, and 60 months.
Material and Methods:
This analysis includes 282 CHAMACOS children who had maternal serum DDT/DDE levels and complete 24-, 42-, and 60-month follow-up data. In utero exposure to o,p′-DDT, p,p′-DDT, and p,p′-DDE was measured by ID-high-resolution mass spectrometry in maternal serum collected at 26 weeks gestation or delivery and reported as lipid-adjusted values (ng/g) and considered as either continuous (log10) or categorical variables (tertiles). At the 24-, 42-, and 60-month follow-ups, standing height (cm) and weight (g) were measured. Body mass index (BMI) was calculated as weight in kilograms divided by height in meters squared. BMI-for-age percentiles were calculated for each child using 2000 Centers for Disease Control and Prevention growth charts. Overweight was defined as ≥95th percentile of the sex-specific BMI for age growth charts.
At 24 months, 45 (16.0%) children were overweight. Overweight prevalence was inversely related with exposure to both p,p′-DDT [I: 1.55–9.09 ng/g, (20.2%); II: 9.10–23.2 ng/g, (14.9%); and III: 23.3–33.174 ng/g (12.8%)] and p,p′-DDE [I: 48.8–737.3 ng/g, (18.1%); II: 737.4–1717.9 ng/g, (18.1%); and III: 1735.2–159,303.3 ng/g, (11.7%)], with the highest exposure tertile having the lowest prevalence of overweight.
The multivariate risk of overweight at 24, 42, and 60 months will be presented. To our knowledge, this is the first epidemiologic study of the relation of in utero DDT/DDE exposure and child overweight.