ISEE 2007 CONFERENCE ABSTRACTS SUPPLEMENT: Abstracts
Evidence and Risk Assessment Division, Center for Chronic Disease Prevention and Control, Public Health Agency of Canada, Canada.
Exposure to pesticides is recognized as an important environmental factor associated with increased risk of cancer. The study examines the association between exposure to pesticides and the risk of non-Hodgkin lymphoma (NHL) in Canadian women.
Material and Methods:
Mailed questionnaires were completed by 789 incidents, histologically confirmed cases of NHL, and 2492 population controls between 1994 and 1997 in 8 Canadian provinces. Measurement included information on socioeconomic status, lifestyle habits, diet, occupation, or nonoccupational exposure to pesticides and years of exposure. Odds ratios (ORs) and 95% confidence intervals (CIs) were derived through unconditional logistic regression.
Exposure to pesticides had an increased risk of NHL. Compared with no exposure to pesticides, the OR was 1.5 (95% CI, 1.1–2.0). ORs increased with increasing exposure in years to pesticides (OR, 1.2 for 1–3 years exposure and 1.5 for >3 years). It was notable that 65% Canadian women exposed to pesticides at home and 30% in both at home and at work. Only 5% women exposed to pesticides at work.
Case-control and cohort studies have given particular attention to agricultural pesticide use and risk of NHL. Most studies were focused on men. A number of studies reported that occupational exposure to pesticides increased the risk of NHL. We found that nonoccupational exposure to pesticides may play a major role in the etiology of NHL in Canadian women. Our findings add to the evidence that exposure to pesticides increased the risk of NHL.