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doi: 10.1097/EDE.0b013e318125713c
Original Article

Short-Term Effects of Particulate Air Pollution on Male Smokers and Never-Smokers

Wong, Chit-Ming; Ou, Chun-Quan; Lee, Nga-Wing; Chan, King-Pan; Thach, Thuan-Quoc; Chau, Yuen-Kwan; Ho, Sai-Yin; Hedley, Anthony Johnson; Lam, Tai-Hing

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From the School of Public Health, The University of Hong Kong, Hong Kong, China.

Submitted 7 July 2007; accepted 24 May 2007.

Supported by the Hong Kong Health Care & Promotion Fund (#215032). We thank the Hong Kong Health Services Research Committee (#631012) and Hong Kong Council on Smoking and Health for funding the Hong Kong Lifestyle and Mortality (LIMOR) study, from which the data of this study were derived.

Supplemental material for this article is available with the online version of the journal at www.epidem.com; click on “Article Plus.”

Correspondence: Anthony Johnson Hedley, School of Public Health, The University of Hong Kong, 5th Floor, Faculty of Medicine Building, 21 Sassoon Road, Hong Kong, China. E-mail: hrmrajh@hkucc.hku.hk

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Background: Numerous studies have shown that ambient air pollution and smoking are both associated with increased mortality, but until now there has been little evidence as to whether the effects of these 2 factors combined are greater than the sum of their individual effects. We assessed whether smokers are subject to additional mortality risk from air pollution relative to never-smokers.

Methods: This study included 10,833 Chinese men in Hong Kong who died at the age of 30 or above during the period 1 January to 31 December 1998. Relatives who registered for deceased persons were interviewed about the deceased's smoking history and other personal lifestyle factors about 10 years before death. Poisson regression for daily number of deaths was fitted to estimate excess risks per 10 μg/m3 increase in particulate matter with aerodynamic diameter <10 μm (PM10) in male smokers and never-smokers in stratified data, and additional excess risk for smokers relative to never-smokers in combined data.

Results: In smokers there was a significant excess risk associated with PM10 for all natural causes and cardio-respiratory diseases for men age 30 years or older and men 65 or older. For all natural causes, greater excess risk associated with PM10 was observed for smokers relative to never-smokers: 1.9% (95% confidence interval = 0.3% to 3.6%) in men age 30 and older and 2.3% (0.4% to 4.3%) in those age 65 and older.

Conclusions: Ambient particulate air pollution is associated with greater excess mortality in male smokers compared with never-smokers.

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In the Asia Pacific region, smoking and air pollution are among the most important causes of avoidable mortality. The health hazards of both have been widely studied,1–4 but there has been limited assessment of their joint effects. A recent analysis5 of the American Cancer Society cohort showed that mortalities from cardiovascular disease and diabetes were related to both fine particulates (PM2.5) and smoking. The relative risks of death from cardiovascular diseases per 10 μg/m3 change in average exposure were slightly higher in current smokers than never-smokers for all categories of cardiorespiratory diseases under study, but the differences were not significant except for hypertension. A case-crossover analysis6 of a cohort in Bordeaux, France, also showed that mortality risks caused by all natural causes and cardiorespiratory diseases per 10 μg/m3 change in black smoke were slightly higher in current smokers than never-smokers. Smokers in more polluted areas, compared with never-smokers in less polluted areas, had greater declines in lung function, higher excess risks for nonadenocarcinoma lung cancer and for deaths from all natural causes.7–10 However the roles of individual pollutants in the interactions between air pollution and smoking were not assessed in any of these studies. It has been recently recognized that adverse effects of air pollution are stronger in some subgroups of the population. Persons with specific diseases or disadvantaged socioeconomic conditions experience greater excess risks.11–13 However, it is not clear whether unhealthy lifestyle factors such as smoking are responsible for an increased susceptibility to the adverse effects of air pollution. In this study we tested the hypothesis that smokers are more adversely affected by ambient particulate air pollution than never-smokers.

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Study Population and Exposure

This study included 10,833 Chinese men in Hong Kong who died during the period 1 January to 31 December 1998. The informants registering an adult death in 1 of 4 death registries in Hong Kong were asked by a trained interviewer to provide information through a standardized questionnaire about the decedent, while waiting in the registry for the death certificate. The questionnaire included individual information for each decedent about social and demographic characteristics, and smoking status, and other lifestyle habits 10 years before death. Assistance in completion of the questionnaire by trained interviewers was provided for illiterate informants and for clarification of questions. A detailed description of the design and conduct of the investigation had been published elsewhere.2

The present analysis included male never-smokers and daily smokers who smoked at least one cigarette per day 10 years before death. Only men were included, as regular daily smoking in women was less prevalent (13%) than in men (51%).

The unique death registration number was linked to the Hong Kong Department of Health databases to obtain the certified underlying cause of death. The date of death was linked to the Environmental Protection Department databases14 from 8 monitoring stations for daily 24-hour concentrations of particulate matter with aerodynamic diameter <10 μm (PM10) and to the Hong Kong Observatory15 for daily temperature and relative humidity data. The daily PM10 concentrations among the 8 monitoring stations are highly correlated (Spearman correlation coefficient ranging from 0.86 to 0.96), and the population density (6.8 millions in 1092 km2) of Hong Kong is very high; it is therefore most likely valid to compute the overall arithmetic mean daily PM10 concentrations of the 8 stations after eliminating discrepancies between stations, and use them as a proxy measure for environmental exposure. The Ethics Committee of the institute where this study was carried out has approved the study proposal.

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Major Outcomes

The underlying cause of death was coded according to the International Classification of Disease 9th revision (ICD-9). The health outcomes were deaths from all natural causes (ICD-9 1-799) and for cardiorespiratory diseases (ICD-9 390-519). We did analysis for all ages (ie, age 30+) and for the 65 or older age (age 65+) group to show the results for the complete data and for the older population.

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Risk Assessment

We defined 2 measures of mortality risks; excess risk (ER) of death per 10 μg/m3 increase in pollutant for smokers and never-smokers, and difference in ER for air pollution effects in smokers relative to never-smokers. The 95% confidence intervals (CIs) for the ERs were also computed.

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Statistical Methods

Time-series count data were stratified according to smoking status of the deceased 10 years before death. Generalized additive Poisson regression model for daily counts Yt at calendar day t (t = 1, 2…365) of each health outcome was constructed. The variables in the model were day of the week, holiday, influenza epidemic indicators, temperature and relative humidity for observable confounding variables Zt, and a smoothing function of t (S(t, df), t = 1, 2, 3…365) defined with certain degrees of freedom (df) for confounding variables that are not directly observable but may be related to long-term trends and seasonal variations of the data.16 Thus,

where A and g are coefficients for the constant term and Zt the confounding variables of the regression model.

We then combined the stratified data with a dummy variable defined for smoking status (C, 1 for smokers and 0 for never-smokers). Poisson regression model for the combined data was specified as

where h is the coefficient for the variable C of the regression model.

Poisson regression Model 1 for stratified data and Model 2 for the combined data were fitted with a certain degrees of freedom for temperature, humidity and time until coefficients of partial autocorrelation function were less than around 0.1 and free from discernible patterns. Then, PM10 concentration variable (X) at concurrent and previous 1–3 days was separately entered into Equation 1, and the effect of PM10 in smokers and never-smokers was assessed by the coefficient associated with X. A product of C and X (CX) and the individual variable X were then entered into Equation 2, from which the additional effect (ie, difference in effects of air pollution for smokers relative to never-smokers) was assessed by the coefficient of the CX term. Additionally, we fitted an unconstrained distributed lag model, simultaneously with inclusion of PM10 concentrations at concurrent and previous 1–3 days and their interaction terms with smoking, to estimate the overall interaction between smoking and air pollution.

Equation 1
Equation 1
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Equation 2
Equation 2
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Two types of sensitivity analyses were performed. Using case-crossover analysis, we compared PM10 levels at the day of individual death (ie, case) with the levels 7 days before and 7 days after death (ie, 2 controls). We also evaluated excess risk of mortality associated with PM10 and additional ER in smokers compared with never-smokers using conditional logistic regression.17 Case-only logistic regression was also applied, with smoking status for individual deaths (no controls) as the dependent variable and PM10 concentration as the independent variable, to detect the interaction between PM10 and smoking status. The case-only approach does not depend on the restrictive assumption for other time-varying factors, or on the development of the core model required in Poisson regression.18,19 Finally we assessed copollutant effects on estimates for the interaction effects between smoking and PM10 by entering the terms for main effect and the product between the smoking variable and the concentration for each of the 3 copollutants. All analysis was performed using R 2.0.1 program and Stata 8.2 statistical package (StataCorp, College Station, TX).

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A total of 4182 male never-smokers and 6901 male smokers were included in the study. Compared with smokers, never-smokers were more likely to be older, locally born, better educated, and living in self-owned housing (Table 1).

Table 1
Table 1
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During the study period, the mean daily number of all deaths attributable to natural causes was 37.4, of which 16.8 were from cardiorespiratory diseases. The mean PM10 concentration was 48.1 μg/m3, temperature 24.0°C, and relative humidity 79.2% (Table 2).

Table 2
Table 2
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Table 3 presents separate estimates of PM10 effects for smokers and never-smokers. In smokers, the most significant effects of PM10 were associated with exposures at zero or 2 days before death. Among smokers age 30 or more, the excess risks for exposures 2 days before death were 1.8% per 10 μg/m3 increase in PM10 (95% CI = 0.5% to 3.1%) for all natural causes, and 2.3% (0.2% to 4.4%) for cardio-respiratory diseases. The same excess risks for smokers of age 65+ were 2.4% (0.7% to 4.1%) and 2.6% (0.3% to 5.0%). In never-smokers, no excess risks were observed.

Table 3
Table 3
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Table 4 shows the results for interaction between smoking and PM10, namely, the additional ER of death associated with PM10 in smokers compared with never-smokers. The additional ER of death for exposures 2 days before death from all natural causes in smokers compared with never-smokers, were 1.9% (0.3% to 3.6%) for ages 30+ and 2.2% (0.2% to 4.2%) for ages 65+. The corresponding additional ER caused by cardiorespiratory diseases were 2.2% (−0.4% to 4.8%) and 2.4% (−0.2% to 5.2%; Table 4). The estimates of additional ER from the unconstrained distributed lag model were generally larger than those at individual lag days (Table 4).

Table 4
Table 4
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The estimates by case-crossover analyses were roughly similar but less precise than estimates from single-lag Poisson regression model (Table 4). Additional ERs in smokers compared with never-smokers using case-only logistic regression were almost identical to those obtained by single-lag Poisson regression model. The estimated effect modification of smoking on PM10 effects changed slightly after adjustment for the main effects of each of the 3 copollutants (data now shown) and increased to a greater extent after also adjustment for their interactions with smoking (Supplementary Table 1, available with the online version of the article).

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Health effects of air pollution estimated from daily time-series modeling have been increasingly used in public health decision-making.20,21 Health effect estimates based on data from routinely collected whole population mortality, health service utilization, or territory-wide environmental surveillance data,21,22 are representative of the population. Observable confounding effects from environmental covariates, which vary with time, can be controlled by their inclusion in the core model; unobservable confounding responsible for seasonal and long-time trends can be controlled by inclusion of a smoothing function of the time variable into the Poisson regression model.16,23 In all the core models we rigorously checked that the residuals are independent and random, by well-established model diagnostics using partial autocorrelation function plots, to minimize any residual confounding effects.

Although personal risk factors are unlikely to confound time-series studies of air pollution effects because they usually do not change over a short period, these factors may modify the short-term effects of air pollution. The health effect assessment based on the whole population in daily time-series studies is a good measure of effects for all subpopulations provided that health effects are homogenous within the population. If air pollution effects vary among subpopulations, (such as the differing effects we have shown between smokers and never-smokers), the effects for more susceptible subgroups (such as smokers) would be underestimated using overall effect estimates that do not take into account the interaction between this risk factor and air pollution exposure.

We observed substantial effects of PM10 in smokers, whereas the effects among never-smokers were not conclusive. We cannot determine whether the true effects for never-smokers are close to or equal to the null. One year of data, may not provide enough power to address this question; a previous simulation study showed that with one-year data the power to detect an excess risk of 2% is almost 100% and to detect an excess risk of 0.5% is 30%.24 However, even with this limitation it is apparent that smokers are at higher risk than nonsmokers from air pollution effects.

Although time-series analysis is the most commonly used method for assessing the short-term effects of air pollution, to our knowledge, this is the first time-series study to examine effect modification by an individual lifestyle factor through examining the potential interaction between the fixed individual factor and time-varying concentrations of air pollution. We found positive additional ER of mortality associated with PM10 in smokers compared with never-smokers. Sensitivity analyses illustrated that the estimates of additional ER from Poisson regression were robust against 2 alternative statistical models. The estimates by case-crossover analysis were roughly similar but less precise, with larger standard error of effect estimates than those using Poisson regression, consistent with a previous report.25 In this analysis, the case-only approach provided almost identical estimates to those using Poisson regression, confirming the relationship between these 2 methods demonstrated previously.18,19 Time-invariant factors, such as socioeconomic status, are associated with smoking but do not vary between the levels of ambient air pollution, so such factors should not confound the estimation in case-only approach. Further, the interaction effects did not diminish after adjustment for each copollutant nitrogen dioxide, ozone or sulfur dioxide, for the main effects and for the interaction effects between copollutants and smoking status of the individuals.

A number of mechanisms could explain the positive interaction between smoking and ambient particulate pollution on mortality. A possible mechanism induced by smoking may operate through decreased clearance and increased deposition and retention of particles. In a chamber study after exposure to iron oxide particles (2.9 μm aerodynamic diameter), the alveolar long-term clearance kinetics revealed a mean half-time of 124 days in healthy nonsmokers and 208 days in smokers.26 Mortensen et al27 reported faster mucociliary clearance in lifelong nonsmokers than in ex-smokers. Both mainstream and sidestream smoke inhibit ciliary beat frequencies and in some cases completely stop ciliary action.28,29 Chronic smoking has been shown to induce ciliary damage, nonreversible even after a long period of smoking cessation.30 On the other hand, on-site measurement has shown that smokers had a significantly higher total respiratory system deposition of PM2.5 than nonsmokers.31

It has been established that ultrafine particles are able to penetrate the human lung and enter the systemic circulation after inhalation.32 Many laboratory and epidemiologic studies have indicated that cigarette smoke induces structural disruption of the airway epithelial barrier33 and causes vascular endothelial dysfunction,34,35 thus increasing particulate entry (and even uptake) into the arterial wall and exacerbating consequent harmful effects. The clearance of particles penetrated and deposited is mainly subject to the macrophage-mediated phagocytosis and digestion. However, smoking has a long-term chronic effect on many important aspects of immune responses, such as neutrophil kinetics (eg, suppression of chemotaxis and phagocytosis),36 function of lymphocytes and cytokines levels (eg, interleukin 1β and interleukin-6).37 A recent case-control study found that PM2.5 concentrations were associated with absolute neutrophil counts and white blood cell counts in nonsmokers but not in smokers.38 This impairment of proper immune response in smokers may inhibit the recognition and removal of particulate matter in the body. Furthermore, smoking is associated with oxidation and decreased concentrations of the major endogenous antioxidant, glutathione39 which would exacerbate oxidative stress induced by particulate air pollution.40 Lastly, heritability may play a role in etiologic mechanism, although little about this has been studied to date. The prevalence of some specific genotypes (eg, DRD2 Taq1A and GSTP1-105) is higher in smokers than that in nonsmokers.41 Such genotypes influence smoking behavior, including the initiation and dependence,42 and effects of smoking on health,43 and people with such genotypes may be more susceptible to the effects of exposure to air pollution.44 Taken together, these factors may explain why smoking may exacerbate the adverse effects of inhaled particulate air pollution, and why smokers may suffer more than never-smokers from air pollution.

Our findings could have public health impact. A coherent public health policy aimed at the reduction of avoidable mortality from air pollution should target both environmental air quality and tobacco control. The elimination of either one of these 2 exposures can lead to 2 benefits: one from avoiding the adverse effects of the exposure that has been eliminated, and the other from avoiding the interaction of the 2 exposures. Public health policy in Hong Kong, as elsewhere, needs to be evidence-driven; otherwise the actions of policy makers and lawmakers are likely to be inadequate or challenged by vested interests. In addition, the results of this study can be incorporated into health promotion programs to motivate more smokers to quit, especially those who are concerned about air pollution.

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We thank Deacon Lee, Aberdeen University Medical School, for his contribution to the literature review and assistance in clerical work.

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