Skip Navigation LinksHome > November 2005 - Volume 16 - Issue 6 > Childhood Asthma and Exposure to Traffic and Nitrogen Dioxid...
Epidemiology:
doi: 10.1097/01.ede.0000181308.51440.75
Original Article

Childhood Asthma and Exposure to Traffic and Nitrogen Dioxide

Gauderman, W James*; Avol, Edward*; Lurmann, Fred†; Kuenzli, Nino*; Gilliland, Frank*; Peters, John*; McConnell, Rob*

Free Access
Supplemental Author Material
Article Outline
Collapse Box

Author Information

From the *Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California; and †Sonoma Technology, Inc., Petaluma, California.

Submitted 12 October 2004; accepted 7 February 2005.

Supported in part by the California Air Resources Board (Contract A033-186), the National Institute of Environmental Health Sciences (5P30ES07048 and 1P01ES11627), the Southern California Particle Center and Supersite, the Environmental Protection Agency (grant R 82670801), and the Hastings Foundation.

Supplemental material for this article is available with the online version of the journal at www.epidem.com; click on “Article Plus.”

Correspondence: W. James Gauderman, Department of Preventive Medicine, University of Southern California, 1540 Alcazar St., Suite 220, Los Angeles, CA 90089. E-mail: jimg@usc.edu.

Collapse Box

Abstract

Background: Evidence for a causal relationship between traffic-related air pollution and asthma has not been consistent across studies, and comparisons among studies have been difficult because of the use of different indicators of exposure.

Methods: We examined the association between traffic-related pollution and childhood asthma in 208 children from 10 southern California communities using multiple indicators of exposure. Study subjects were randomly selected from participants in the Children's Health Study. Outdoor nitrogen dioxide (NO2) was measured in summer and winter outside the home of each child. We also determined residential distance to the nearest freeway, traffic volumes on roadways within 150 meters, and model-based estimates of pollution from nearby roadways.

Results: Lifetime history of doctor-diagnosed asthma was associated with outdoor NO2; the odds ratio (OR) was 1.83 (95% confidence interval = 1.04–3.22) per increase of 1 interquartile range (IQR = 5.7 ppb) in exposure. We also observed increased asthma associated with closer residential distance to a freeway (1.89 per IQR; 1.19–3.02) and with model-based estimates of outdoor pollution from a freeway (2.22 per IQR; 1.36–3.63). These 2 indicators of freeway exposure and measured NO2 concentrations were also associated with wheezing and use of asthma medication. Asthma was not associated with traffic volumes on roadways within 150 meters of homes or with model-based estimates of pollution from nonfreeway roads.

Conclusions: These results indicate that respiratory health in children is adversely affected by local exposures to outdoor NO2 or other freeway-related pollutants.

Back to Top | Article Outline

ArticlePlus

Click on the links below to access all the ArticlePlus for this article.

Please note that ArticlePlus files may launch a viewer application outside of your web browser.

* http://links.lww.com/EDE/A188

Previous studies have demonstrated a link between outdoor air pollution and the occurrence of symptoms in children already diagnosed with asthma.1 However, results are not consistent with respect to whether air pollution causes asthma. Most studies have found little evidence to support an association between community-average exposures to air pollution and community asthma prevalence.2 These study designs failed to account for the variability in exposure resulting from vehicular traffic in urban areas. Asthma has been associated with local variation in traffic patterns within communities in many,3–7 but not all,8–11 studies that have examined the impact of local traffic. One possible reason for the inconsistency in these recent studies is the use of different indicators of traffic-related pollution. Some have measured pollutant exposure at home, some have estimated traffic volume near the home, and some have estimated exposure to traffic-related pollutants at home based on dispersion models. Little work has been done to validate estimates of traffic exposure against measured pollution concentrations. Most studies have been conducted in European cities, which differ from U.S. cities in the layout of streets and homes, and also in the relative proportion of diesel- to gasoline-powered vehicles.

We evaluated several commonly available indicators of traffic exposure and compared them with nitrogen dioxide (NO2) levels measured at the homes of subjects participating in the Children's Health Study. The Children's Health Study was initiated in 1993 with a cohort of school-aged children from 12 southern California communities representing a wide range in air quality. To date, this study has reported associations between air pollution and several outcomes, including lung function,12–15 respiratory symptoms in asthmatics,16,17 and asthma incidence.18 These analyses have relied on comparisons of average health across communities in relation to the pollution levels measured at a central site monitor in each community. In 2000, we conducted a study to measure NO2 levels at a random sample of children's homes within each of the study communities. We examine how local variation in NO2 and indicators of exposure to traffic-related pollutants are related to each other, and whether they are associated with lifetime prevalence of asthma and asthma-related outcomes.

Back to Top | Article Outline

METHODS

Study Subjects

In calendar year 2000, we measured outdoor NO2 levels at the homes of randomly selected participants in the Children's Health Study. Eligible children included those who were originally enrolled as fourth graders (average age = 10 years) in 1993 (cohort 1) or 1996 (cohort 2), with the additional criteria that in 2000, they were still actively participating in the study and had lived in the same home since study enrollment. We excluded 2 of the 12 study communities (Lompoc and Lake Arrowhead) from this study, because neither has any major sources of traffic. From the pool of 890 eligible subjects, we randomly sampled 229 children for NO2 monitoring. Samplers were deployed outside each home for 2-week periods in the summer and fall of 2000. Valid measurements in both seasons were obtained at 208 (91%) of the homes. Reasons for invalid measurements included lost samplers, subjects who moved, and difficulties with field access or deployment. The study protocol was approved by the Institutional Review Board for Human Studies at the University of Southern California, and informed consent was provided by a parent or legal guardian for all study subjects.

Back to Top | Article Outline
Nitrogen Dioxide Sampling

Ambient NO2 was sampled with Palmes tubes.19 These diffusion-based samplers have been widely used in several microenvironmental and personal air quality studies.20–22 We deployed samplers outside the homes of study subjects, thus avoiding previously identified confounders such as indoor nitrous acid formation, gas stoves, or wall heaters. Samplers were attached at the roofline eaves, signposts, or rain gutters at an approximate height of 2 meters above the ground, oriented in a downward position and protected by an oversized paper cup. Duplicate samplers and field travel blanks were randomly assigned to approximately 10% of the subjects’ homes. Samplers were deployed for 2-week periods in both summer (mid-August) and fall (mid-November) in all communities. Deployment across communities was accomplished over a 4-day period at the start of the summer and fall field sampling periods. Within any 1 community, samplers at all locations were deployed within a 4-hour period, and 2 weeks later the samplers were retrieved within a 4-hour period. Samplers were transported to and from the field in cooled portable ice chests. The samplers were prepared for field use and analyzed at the Harvard School of Public Health.

Back to Top | Article Outline
Traffic Exposures

We characterized exposure of each study participant to traffic-related pollutants by 3 metrics: (1) proximity of the residence to the nearest freeway; (2) average number of vehicles traveling within 150 meters of the residence each day, including vehicles on freeways, arterials, major collector roads, and (where available) on minor collector roads; and (3) model-based estimates of traffic-related air pollution at the residence, derived from dispersion models that incorporate distance to roadways, vehicle counts, vehicle emission rates, and meteorologic conditions. Methods used to estimate each of these exposure factors are described subsequently.

Residence addresses were standardized and their locations geocoded using the TeleAtlas database and software (Tele Atlas Inc., Menlo Park, CA, www.na.teleatlas.com). We used the TeleAtlas MultiNet USA database, a comprehensive geo-positioning-satellite-accurate database of roadways, for all analyses because it is more accurate than the standard files available from the U.S. Census. To estimate distance to the nearest freeway, we used ERSI ArcGIS Version 8.3 (ESRI, Redland, CA, www.esri.com) software tools to calculate the distance from each residence to the nearest interstate freeway, U.S. highway, or limited access highway. In these calculations, each direction of travel was represented as a separate roadway, and the “distance to nearest freeway” was the shortest distance from the residence to the middle of the nearest set of lanes of the freeway.

To estimate vehicle counts near homes, annual average daily traffic volumes were obtained from the California Department of Transportation (CALTRANS) Highway Performance Monitoring System for the year 2000. The traffic volumes were transferred from the CALTRANS roadway network to the TeleAtlas networks using previously described methods.23 The hourly traffic volumes on weekdays and weekend days were estimated from the annual average daily traffic volumes and the average diurnal and day-of-week freeway and nonfreeway traffic variations observed in Southern California. These data were used to calculate the daily average number of vehicles traveling within 150 meters of each residence, weighted by inverse distance from the home to each road. This local traffic density was expressed as traffic volume per square meter.

To obtain model-based estimates of traffic-related pollution exposure, we used the CALINE4 line-source air-quality dispersion model.24 Principal model inputs included roadway link geometry, link traffic volumes, meteorologic conditions (wind speed and direction, atmospheric stability, and mixing heights), and vehicle emission rates. The 5-year average joint distributions of wind speeds and directions were obtained from 1 surface-monitoring station in or near each study community. The dispersion model was applied to simulate the transport and dispersion of NOx as a chemically inert pollutant. Although NO, NO2, and ozone undergo rapid atmospheric chemical reactions immediately downwind of sources, NOx can be treated as a chemically inert pollutant for the first hour of transport from sources because the time-scale for NOx oxidation is 10 to 20 hours in urban atmospheres.25 Vehicle NOx emission rates were obtained from the California Air Resources Board's EMFAC2002 vehicle emissions model. Concentrations of NO2 were estimated by applying the annual average ratio of observed NO2 to NOx for each hour of the day (from the community central site monitor) to the CALINE4 model's estimated NOx concentrations. We estimated the contribution to residential exposure separately for freeway and for nonfreeway traffic.

Ambient NO2 concentrations in the community are a result of meteorologic transport of pollutants into the community, local point and area source emissions, and local mobile source emissions. The CALINE4 model was used to model NO2 from local traffic in each community and, therefore, always predicts concentrations lower than the total NO2 from all sources. Separate regional modeling analysis has indicated that local mobile source emissions contribute 12% to 68% of the average NO2 in the study communities.23 For comparison purposes, we also generated exposure assignments based on fine particulate matter (PM) and carbon monoxide (CO) emission factors. Model-based estimates of NO2, PM, and CO were very highly correlated with one another (R > 0.90), indicating that the NO2-based estimates we use in this article should be considered an estimate of traffic-related pollution in general rather than simply exposure to this specific pollutant.

Back to Top | Article Outline
Questionnaire Data

When we originally enrolled subjects as fourth graders, each subject's parent or legal guardian completed a baseline medical history questionnaire. Asthma was defined as a “yes” response to the question “Has a doctor ever diagnosed your child as having asthma?” This questionnaire was also used to determine whether the child had recently (within the last 12 months) wheezed, recently wheezed during exercise, or was currently using any type of medication to control asthma. Questions about potential risk factors for asthma included parental income or education, environmental tobacco smoke exposure, in utero exposure to maternal tobacco smoking, and presence in the home of mildew, water damage, gas stove, pests, and pets.

Back to Top | Article Outline
Statistical Analysis

We used logistic regression to model the relationship of each traffic measure, including measured NO2 at the home and the traffic indicators described previously, with baseline asthma prevalence in the 208 study participants. A natural-log transformation of each traffic indicator was used in these analyses, because the distribution of each variable was positively skewed. All models included adjustments for sex, race, Hispanic ethnicity, cohort (whether the subject was enrolled in 1993 or 1996), and indicator variables for study community. We considered separate models for 2-week average NO2 concentrations measured in summer and in winter and for the 4-week average across seasons. Odds ratios (ORs) for asthma in analyses of measured NO2 concentrations were scaled to an increase of 5.7 ppb, the average interquartile range (IQR) in 4-week average NO2 within the 10 communities. ORs for the traffic indicators were also scaled to 1 IQR in exposure (specifically 1.2 km for distance to the nearest freeway; 2720 vehicles per m2 per day for traffic volumes within 150 meters; and 0.64, 0.49, and 1.27 ppb for model-based estimates of NO2 from freeways, nonfreeways, and all roads, respectively).

Back to Top | Article Outline

RESULTS

Doctor-diagnosed asthma was reported by 31 (15%) of the 208 children, with variability in prevalence across communities (Table 1). Overall community-average NO2 levels measured at homes ranged from 12.9 ppb in Atascadero to 51.5 ppb in San Dimas, with similar patterns across communities in summer and winter. The NO2 levels (average of summer and winter) measured at homes are shown in Figure 1. Within each community, there was substantial variation in NO2 levels from home to home. Although the amount of variation in NO2 was generally larger in more polluted communities, there were some exceptions. For example, there was little variation in the relatively high NO2 community of Mira Loma, whereas there was considerable variation in the lower NO2 community of Alpine.

Table 1
Table 1
Image Tools
Figure 1
Figure 1
Image Tools

The average NO2 concentration measured at homes was associated with asthma prevalence (Table 2). For each increase of 5.7 ppb in average NO2, the OR for asthma increased by 1.83 (95% CI = 1.04–3.21). Odds ratios were similar whether based on summer-only (1.55) or winter-only (1.50) measurements. The effect of average NO2 was of similar magnitude after adjustment for several potential confounders, including socioeconomic status of participants and housing characteristics (Table 2).

Table 2
Table 2
Image Tools

Measured NO2 concentrations at homes were correlated with residential distance from the nearest freeway and with model-based estimates of traffic-related pollution from roadways (Appendix Table, available with the online version of this article). In each community, we observed negative correlations between NO2 concentration and distance of the home to the freeway. The overall correlation between NO2 and freeway distance, adjusted for community, was R = −0.54. The corresponding correlations of measured NO2 with model-based estimates were 0.56 for pollution from freeways and 0.34 for pollution from nonfreeways. In each community, measured NO2 was more strongly correlated with estimates of freeway-related pollution than with nonfreeway pollution. Measured NO2 was less correlated with traffic counts within 150 meters of homes (R = 0.24), with inconsistent patterns of correlations from community to community.

Both distance to the freeway and the model-based estimate of freeway-related pollutants were associated with asthma history (Table 3). Asthma prevalence was higher with decreasing distance from the freeway; specifically when comparing the 25th to 75th percentile of freeway distance, the OR was 1.89 (95% CI = 1.19–3.02). For the comparison of 75th to 25th percentile of model-based pollutant exposure from freeways, the OR was 2.22 (1.36–3.63). Asthma was not associated with traffic volumes or with model-based exposure to nonfreeway roads. The associations observed with freeway distance and model-based pollution from freeways were robust to adjustment for all of the potential confounders shown in Table 2 (data not shown).

Table 3
Table 3
Image Tools

Measured NO2 and the 2 freeway-related traffic indicators were also associated with recent wheeze, recent wheeze with exercise, and current use of asthma medication (Table 4). For example, the OR per increase of 5.7 ppb in measured NO2 was 1.72 (1.07–2.77) for recent wheeze and was 2.19 (1.20–4.01) for current use of asthma medication.

Table 4
Table 4
Image Tools
Back to Top | Article Outline

DISCUSSION

We found robust associations of several indicators of exposure to traffic-related air pollution at homes in southern California with lifetime history of asthma, current asthma medication use, recent wheeze, and recent exercise-induced wheeze. Residential distance to a freeway and model-based estimates of freeway traffic-emission exposure at homes were each associated with the prevalence of asthma. Each of these traffic metrics was also correlated with measured concentrations of NO2, and measured NO2 was associated with asthma. Taken as a whole, these results indicate that exposure to outdoor levels of NO2 or other freeway-related pollutants was a significant risk factor for asthma.

A strength of this asthma study is that it used both measured pollution and multiple indicators of exposure to traffic at the same homes in a large number of communities. The results suggest that measuring NO2 or another pollutant is important for validation of the use of traffic measures and for selection of the most appropriate indicator of traffic exposure for the population under study. Those few studies that have measured residential exposure or that have validated models of exposure using measurements of pollutants have generally shown associations with asthma,6,7,26 whereas the failure to validate traffic indicators may explain inconsistent results from several other studies.8–11 In our study, simple distance to a freeway was as strongly and precisely associated with asthma and wheeze as was NO2. It remains to be seen whether the association with this simple and widely available indicator is replicable in other studies or could be used for estimating risk in communities without having to make additional measurements of traffic-related pollutants.

We did not find associations between respiratory health and other indicators of traffic near homes, including modeled pollution from nonfreeway roads and traffic volumes within 150 meters of homes. One possible explanation for this lack of association is that the contribution to pollution levels from these smaller roads (where tens or hundreds of vehicles travel each day) is trivial compared with freeways that dominate the transportation grid in southern California with daily average counts in our communities between 50,000 to 270,000 vehicles. In addition, vehicle counts are accurately measured on freeways but are only estimated on smaller roads where participants lived. Our results are in contrast to several recent (mostly European) studies that have reported associations of asthma with traffic counts in close proximity to the home.6,7,27,28 These differences in results may be partly the result of differences in urban geography and closer proximity of homes in Europe to heavily traveled roadways.

There have been a few other studies of traffic and childhood asthma in the United States. One large study in southern California found no association of asthma prevalence with traffic counts within 550 feet of the home,9 similar to our finding of no association with traffic volumes within 150 meters of the home. Consistent with our findings related to measured NO2, a recent study in northern California29 found an association between measured traffic-related pollutants at schools and childhood asthma.

The observed associations of traffic with asthma are biologically plausible. Increased oxidative and nitrosative stress associated with NO2 exposure may impair respiratory responses to infection and thus result in lung injury and asthma exacerbation.20,30 However, the association of NO2 with asthma prevalence has been extensively evaluated in epidemiologic studies of exposure to indoor sources, often at levels considerably higher than the modest (5.7 ppb) IQR of exposure in our study, and the observed associations have not been consistent.30,31 It is possible that outdoor NO2, which occurs in a complex mixture that includes particulate matter and other pollutants known to affect respiratory health, is a marker of some other traffic-related pollutant(s) responsible for increasing asthma risk. For example, some field studies suggest that the concentration of fine particulate matter, especially black smoke (an indicator of diesel exhaust), varies with nearby high-traffic roads and with NO2.32–35 It has been hypothesized that particulate matter, especially diesel exhaust particulate, may contribute to the development of allergies and asthma.36 Additional research is needed to study the health effects of specific pollutants that occur in complex mixtures of traffic emissions.

A possible limitation of this study is the assessment of asthma by questionnaire, which could be affected by access to care and differences in diagnostic practice among physicians.37 However, we found associations of traffic indicators with recent wheeze and exercise-induced wheeze, 2 symptoms of asthma that are unlikely to be affected by access to care or diagnostic bias. Another limitation is the possibility of poor or biased reporting of asthma by parents. However, self-report of physician-diagnosed asthma has been found to reflect what physicians actually reported to patients, at least in adults, and validity as assessed by repeatability of response is good.38 Self-report of physician diagnosis has been the main criterion for identifying asthma in epidemiologic studies of children and has been recommended as the epidemiologic gold standard because a more precise identification tool is not available.39 Reporting bias is unlikely to have explained the observed associations, because parents were not aware of the specific focus of the study on air pollution at the time the questionnaire was completed. Biased participation with respect to disease status in this substudy is also unlikely, because the prevalence of doctor-diagnosed asthma in the sample of 208 children (15%, Table 1) was not very different from the asthma prevalence in the remaining 668 eligible children (13%, P = 0.56).

Another potential study limitation is that measured NO2 and the traffic metrics were determined after the onset of asthma and extrapolated to earlier in life. However, the systems of freeways and other major roadways in the study communities have been in place and essentially unchanged for many years. We thus expect that the spatial pattern of exposure to traffic emissions from home to home was relatively similar over the lifetimes of these children. Bias could also have occurred if the families of asthmatic children had preferentially moved to a home near a freeway, but this seems unlikely. Additionally, our observed associations were robust to adjustment for factors known to be related to population mobility, housing location, and access to care, including race/ethnicity and indicators of socioeconomic status (as well as household characteristics). This robustness further suggests that our results were not the result of these potential confounders.

These results have both scientific and public health implications. They strengthen an emerging body of evidence that air pollution can cause asthma and that traffic-related pollutants that vary within communities are partly responsible for this association. The current regulatory approach that focuses almost exclusively on regional pollutants merits reevaluation in light of this emerging evidence and in light of the enormous costs associated with childhood asthma.40 In addition, because NO2 may be a surrogate for the pollutant or pollutants responsible for the observed effects, further study is indicated to identify the specific pollutant(s). In this regard, improved physical and chemical characterization of ambient ultrafine particles (including particle number concentration distributions, as well as more traditional chemical analyses) are topics of specific ongoing research interest in southern California and elsewhere.

Back to Top | Article Outline

ACKNOWLEDGMENTS

We are very grateful for input from the external advisory committee to this study, including David Bates, Morton Lippmann, Jonathan Samet, Frank Speizer, John Spengler, and Scott Zeger. We thank Tami Funk of Sonoma Technology for contributing to the assessment of residential distance to freeways, and Robert Weker of the Harvard School of Public Health for preparing and analyzing the Palmes tubes.

Back to Top | Article Outline

REFERENCES

1. Nicolai T. Air pollution and respiratory disease in children: what is the clinically relevant impact? Pediatr Pulmonol Suppl. 1999;18:9–13.

2. Clark NM, Brown RW, Parker E, et al. Childhood asthma. Environ Health Perspect. 1999;107(suppl 3):421–429.

3. Venn A, Lewis S, Cooper M, et al. Local road traffic activity and the prevalence, severity, and persistence of wheeze in school children: combined cross sectional and longitudinal study. Occup Environ Med. 2000;57:152–158.

4. Edwards J, Walters S, Griffiths RK. Hospital admissions for asthma in preschool children: relationship to major roads in Birmingham, United Kingdom. Arch Environ Health. 1994;49:223–227.

5. Hirsch T, Weiland SK, von Mutius E, et al. Inner city air pollution and respiratory health and atopy in children. Eur Respir J. 1999;14:669–677.

6. van Vliet P, Knape M, de Hartog J, et al. Motor vehicle exhaust and chronic respiratory symptoms in children living near freeways. Environ Res. 1997;74:122–132.

7. Nicolai T, Carr D, Weiland SK, et al. Urban traffic and pollutant exposure related to respiratory outcomes and atopy in a large sample of children. Eur Respir J. 2003;21:956–963.

8. Wjst M, Reitmeir P, Dold S, et al. Road traffic and adverse effects on respiratory health in children. BMJ. 1993;307:596–600.

9. English P, Neutra R, Scalf R, et al. Examining associations between childhood asthma and traffic flow using a geographic information system. Environ Health Perspect. 1999;107:761–767.

10. Waldron G, Pottle B, Dod J. Asthma and the motorways—one district's experience. J Public Health Med. 1995;17:85–89.

11. Kramer U, Koch T, Ranft U, et al. Traffic-related air pollution is associated with atopy in children living in urban areas. Epidemiology. 2000;11:64–70.

12. Peters JM, Avol E, Gauderman WJ, et al. A study of twelve Southern California communities with differing levels and types of air pollution. II. Effects on pulmonary function. Am J Respir Crit Care Med. 1999;159:768–775.

13. Gauderman WJ, McConnell R, Gilliland F, et al. Association between air pollution and lung function growth in southern California children. Am J Respir Crit Care Med. 2000;162:1383–1390.

14. Avol E, Gauderman W, Tan S, et al. Respiratory effects of relocating to areas of differing air pollution levels. Am J Respir Crit Care Med. 2001;164:2067–2072.

15. Gauderman WJ, Avol E, Gilliland F, et al. The effect of air pollution on lung function development in children aged 10 to 18 years. New Engl J Med. 2004;351:1057–1067.

16. McConnell R, Berhane K, Gilliland F, et al. Air pollution and bronchitic symptoms in southern California children with asthma. Environ Health Perspect. 1999;107:757–760.

17. McConnell R, Berhane K, Gilliland F, et al. Prospective study of air pollution and bronchitic symptoms in children with asthma. Am J Respir Crit Care Med. 2003;168:790–797.

18. McConnell R, Berhane K, Gilliland F, et al. Asthma in exercising children exposed to ozone: a cohort study. Lancet. 2002;359:386–391.

19. Palmes ED, Gunnison AF, DiMattio J, et al. Personal sampler for NO2. Journal of the American Industrial Hygiene Association. 1976;37:570–577.

20. Linaker CH, Coggon D, Holgate ST, et al. Personal exposure to nitrogen dioxide and risk of airflow obstruction in asthmatic children with upper respiratory infection. Thorax. 2000;55:930–933.

21. Alm S, Mukala K, Pasanen P, et al. Personal NO2 exposures of preschool children in Helsinki. J Expo Anal Environ Epidemiol. 1998;8:79–100.

22. Samet J, Lambert W, Skipper B, et al. Nitrogen dioxide and respiratory illnesses in infants. Am Rev Respir Dis. 1993;148:1258–1265.

23. Wu J, Lurmann F, Winer A, et al. Development of an individual exposure model for application to the Southern California children's health study. Atmos Environ. 2005;39:259–273.

24. Bensen P. CALINE4—A Dispersion Model for Predicting Air Pollution Concentrations Near Roadways. Sacramento: California Department of Transportation; 1989.

25. Trainer M, Parrish D, Goldan P, et al. Review of observation-based analysis of the regional factors influencing ozone concentrations. Atmos Environ. 2000;34:2045–2061.

26. Brauer M, Hoek G, Van Vliet P, et al. Air pollution from traffic and the development of respiratory infections and asthmatic and allergic symptoms in children. Am J Respir Crit Care Med. 2002;166:1092–1098.

27. Venn AJ, Lewis SA, Cooper M, et al. Living near a main road and the risk of wheezing illness in children. Am J Respir Crit Care Med. 2001;164:2177–2180.

28. Zmirou D, Gauvin S, Pin I, et al. Traffic related air pollution and incidence of childhood asthma: results of the Vesta case–control study. J Epidemiol Community Health. 2004;58:18–23.

29. Kim JJ, Smorodinsky S, Lipsett M, et al. Traffic-related air pollution near busy roads: the East Bay Children's Respiratory Health Study. Am J Respir Crit Care Med. 2004;170:520–526.

30. Health effects of outdoor air pollution. Part 2. Committee of the Environmental and Occupational Health Assembly of the American Thoracic Society. Am J Respir Crit Care Med. 1996;153:477–498.

31. Bates DV. Observations on asthma. Environ Health Perspect. 1995;103(suppl 6):243–247.

32. Brauer M, Hoek G, van Vliet P, et al. Estimating long-term average particulate air pollution concentrations: application of traffic indicators and geographic information systems. Epidemiology. 2003;14:228–239.

33. Fischer PH, Hoek G, Van Reeuwijka H, et al. Traffic-related differences in outdoor and indoor concentrations of particles and volatile organic compounds in Amsterdam. Atmos Environ. 2000;34:3713–3722.

34. Roorda-Knape MC, Janssen NAH, de Hartog JJ, et al. Air pollution from traffic in city districts near major motorways. Atmos Environ. 1998;32:1921–1930.

35. Seaton A, Dennekamp M. Hypothesis: ill health associated with low concentrations of nitrogen dioxide—an effect of ultrafine particles? Thorax. 2003;58:1012–1015.

36. Li N, Kim S, Wang M, et al. Use of a stratified oxidative stress model to study the biological effects of ambient concentrated and diesel exhaust particulate matter. Inhal Toxicol. 2002;14:459–486.

37. Samet JM. Epidemiologic approaches for the identification of asthma. Chest. 1987;91:74S–78S.

38. Ehrlich RI, Du Toit D, Jordaan E, et al. Prevalence and reliability of asthma symptoms in primary school children in Cape Town. Int J Epidemiol. 1995;24:1138–1145.

39. Burr ML. Diagnosing asthma by questionnaire in epidemiological surveys [Editorial]. Clin Exp Allergy. 1992;22:509–510.

40. Smith DH, Malone DC, Lawson KA, et al. A national estimate of the economic costs of asthma. Am J Respir Crit Care Med. 1997;156:787–793.

Cited By:

This article has been cited 121 time(s).

Pulmonary Pharmacology & Therapeutics
Airway epithelial regulation of allergic sensitization in asthma
Poynter, ME
Pulmonary Pharmacology & Therapeutics, 25(6): 438-446.
10.1016/j.pupt.2012.04.005
CrossRef
American Journal of Respiratory and Critical Care Medicine
Early-Life Air Pollution and Asthma Risk in Minority Children The GALA II and SAGE II Studies
Nishimura, KK; Galanter, JM; Roth, LA; Oh, SS; Thakur, N; Nguyen, EA; Thyne, S; Farber, HJ; Serebrisky, D; Kumar, R; Brigino-Buenaventura, E; Davis, A; LeNoir, MA; Meade, K; Rodriguez-Cintron, W; Avila, PC; Borrell, LN; Bibbins-Domingo, K; Rodriguez-Santana, JR; Sen, S; Lurmann, F; Balmes, JR; Burchard, EG
American Journal of Respiratory and Critical Care Medicine, 188(3): 309-318.
10.1164/rccm.201302-0264OC
CrossRef
Journal of Allergy and Clinical Immunology
Altered microRNA profiles in bronchoalveolar lavage fluid exosomes in asthmatic patients
Levanen, B; Bhakta, NR; Paredes, PT; Barbeau, R; Hiltbrunner, S; Pollack, JL; Skold, CM; Svartengren, M; Grunewald, J; Gabrielsson, S; Eklund, A; Larsson, BM; Woodruff, PG; Erle, DJ; Wheelock, AM
Journal of Allergy and Clinical Immunology, 131(3): 894-+.
10.1016/j.jaci.2012.11.039
CrossRef
Bmc Public Health
Modifiable exposures to air pollutants related to asthma phenotypes in the first year of life in children of the EDEN mother-child cohort study
Zhou, CL; Baiz, N; Zhang, TH; Banerjee, S; Annesi-Maesano, I
Bmc Public Health, 13(): -.
ARTN 506
CrossRef
Multidisciplinary Respiratory Medicine
Climate change, air pollution and extreme events leading to increasing prevalence of allergic respiratory diseases
D'Amato, G; Baena-Cagnani, CE; Cecchi, L; Annesi-Maesano, I; Nunes, C; Ansotegui, I; D'Amato, M; Liccardi, G; Sofia, M; Canonica, WG
Multidisciplinary Respiratory Medicine, 8(): -.
ARTN 12
CrossRef
Journal of Epidemiology
Effects of Outdoor and Indoor Air Pollution on Respiratory Health of Chinese Children from 50 Kindergartens
Liu, MM; Wang, D; Zhao, Y; Liu, YQ; Huang, MM; Liu, Y; Sun, J; Ren, WH; Zhao, YD; He, QC; Dong, GH
Journal of Epidemiology, 23(4): 280-287.
10.2188/jea.JE20120175
CrossRef
Pediatrics International
Influence of outdoor NO2 exposure on asthma in childhood: Meta-analysis
Takenoue, Y; Kaneko, T; Miyamae, T; Mori, M; Yokota, S
Pediatrics International, 54(6): 762-769.
10.1111/j.1442-200X.2012.03674.x
CrossRef
Human Heredity
Joint Analysis for Integrating Two Related Studies of Different Data Types and Different Study Designs Using Hierarchical Modeling Approaches
Li, R; Conti, DV; Diaz-Sanchez, D; Gilliland, F; Thomas, DC
Human Heredity, 74(2): 83-96.
10.1159/000345181
CrossRef
Revue De Pneumologie Clinique
Environmental pollution and allergy: Immunological mechanisms
Ple, C; Chang, Y; Wallaert, B; Tsicopoulos, A
Revue De Pneumologie Clinique, 69(1): 18-25.
10.1016/j.pneumo.2012.11.007
CrossRef
Atmospheric Environment
Remote sensing of exposure to NO2: Satellite versus ground-based measurement in a large urban
Bechle, MJ; Millet, DB; Marshall, JD
Atmospheric Environment, 69(): 345-353.
10.1016/j.atmosenv.2012.11.046
CrossRef
Environmental Health
Perceived annoyance and asthmatic symptoms in relation to vehicle exhaust levels outside home: a cross-sectional study
Modig, L; Forsberg, B
Environmental Health, 6(): -.
ARTN 29
CrossRef
Journal of Exposure Science and Environmental Epidemiology
Health effects of air pollution observed in cohort studies in Europe
Brunekreef, B
Journal of Exposure Science and Environmental Epidemiology, 17(): S61-S65.
10.1038/sj.jes.7500628
CrossRef
Clinical and Experimental Allergy
Effects of climate change on environmental factors in respiratory allergic diseases
D'Amato, G; Cecchi, L
Clinical and Experimental Allergy, 38(8): 1264-1274.
10.1111/j.1365-2222.2008.03033.x
CrossRef
Environmental Health Perspectives
A longitudinal study of indoor nitrogen dioxide levels and respiratory symptoms in inner-city children with asthma
Hansel, NN; Breysse, PN; McCormack, MC; Matsui, EC; Curtin-Brosnan, J; Williams, DL; Moore, JL; Cuhran, JL; Diette, GB
Environmental Health Perspectives, 116(): 1428-1432.
10.1289/ehp.11349
CrossRef
Transportation Research Record
Diesel Truck Traffic in Low-income and Minority Communities Adjacent to Ports Environmental Justice Implications of Near-Roadway Land Use Conflicts
Houston, D; Krudysz, M; Winer, A
Transportation Research Record, (): 38-46.
10.3141/2067-05
CrossRef
Environmental Research Letters
The relationship between air pollution and low birth weight: effects by mother's age, infant sex, co-pollutants, and pre-term births
Bell, ML; Ebisu, K; Belanger, K
Environmental Research Letters, 3(4): -.
ARTN 044003
CrossRef
Journal of Allergy and Clinical Immunology
The protective effect of community factors on childhood asthma
Gupta, RS; Zhang, XY; Sharp, LK; Shannon, JJ; Weiss, KB
Journal of Allergy and Clinical Immunology, 123(6): 1297-1304.
10.1016/j.jaci.2009.03.039
CrossRef
Journal of Exposure Science and Environmental Epidemiology
Personal exposures to traffic-related particle pollution among children with asthma in the South Bronx, NY
Spira-Cohen, A; Chen, LC; Kendall, M; Sheesley, R; Thurston, GD
Journal of Exposure Science and Environmental Epidemiology, 20(5): 446-456.
10.1038/jes.2009.34
CrossRef
Occupational and Environmental Medicine
NO2 and children's respiratory symptoms in the PATY study
Pattenden, S; Hoek, G; Braun-Fahrlander, C; Forastiere, F; Kosheleva, A; Neuberger, M; Fletcher, T
Occupational and Environmental Medicine, 63(): 828-835.
10.1136/oem.2006.025213
CrossRef
Lancet
Effect of exposure to traffic on lung development from 10 to 18 years of age: a cohort study
Gauderman, WJ; Vora, H; McConnell, R; Berhane, K; Gilliland, F; Thomas, D; Lurmann, F; Avoli, E; Kunzli, N; Jerrett, M; Peters, J
Lancet, 369(): 571-577.
10.1016/S0140-6736(07)60037-3
CrossRef
Environmental Science & Technology
Speciation and chemical evolution of nitrogen oxides in aircraft exhaust near airports
Wood, EC; Herndon, SC; Timko, MT; Yelvington, PE; Miake-Lye, RC
Environmental Science & Technology, 42(6): 1884-1891.
10.1021/es072050a
CrossRef
Thorax
Ambient air pollution triggers wheezing symptoms in infants
Andersen, ZJ; Loft, S; Ketzel, M; Stage, M; Scheike, T; Hermansen, MN; Bisgaard, H
Thorax, 63(8): 710-716.
10.1136/thx.2007.085480
CrossRef
Journal of Exposure Science and Environmental Epidemiology
On exposure and response relationships for health effects associated with exposure to vehicular traffic
Lipfert, FW; Wyzga, RE
Journal of Exposure Science and Environmental Epidemiology, 18(6): 588-599.
10.1038/jes.2008.4
CrossRef
Journal of Exposure Science and Environmental Epidemiology
Intercity transferability of land use regression models for estimating ambient concentrations of nitrogen dioxide
Poplawski, K; Gould, T; Setton, E; Allen, R; Su, J; Larson, T; Henderson, S; Brauer, M; Hystad, P; Lightowlers, C; Keller, P; Cohen, M; Silva, C; Buzzelli, M
Journal of Exposure Science and Environmental Epidemiology, 19(1): 107-117.
10.1038/jes.2008.15
CrossRef
Archivos De Bronconeumologia
Air Pollution and Recent Symptoms of Asthma, Allergic Rhinitis, and Atopic Eczema in Schoolchildren Aged Between 6 and 7 Years
Arnedo-Pena, A; Garcia-Marcos, L; Uruena, IC; Monge, RB; Suarez-Varela, MM; Canflanca, IM; Garrido, JB; Quiros, AB; Varela, ALS; Hernandez, GG; Ontoso, IA; Diaz, CG
Archivos De Bronconeumologia, 45(5): 224-229.
10.1016/j.arbres.2008.10.004
CrossRef
European Respiratory Journal
Association between modelled traffic-related air pollution and asthma score in the ECRHS
Jacquemin, B; Sunyer, J; Forsberg, B; Aguilera, I; Bouso, L; Briggs, D; de Marco, R; Garcia-Esteban, R; Heinrich, J; Jarvis, D; Maldonaldo, JA; Payo, F; Rage, E; Vienneau, D; Kunzli, N
European Respiratory Journal, 34(4): 834-842.
10.1183/09031936.00138208
CrossRef
Environmental Health Perspectives
Association between Local Traffic-Generated Air Pollution and Preeclampsia and Preterm Delivery in the South Coast Air Basin of California
Wu, J; Ren, CZ; Delfino, RJ; Chung, J; Wilhelm, M; Ritz, B
Environmental Health Perspectives, 117(): 1773-1779.
10.1289/ehp.0800334
CrossRef
European Respiratory Journal
Air pollution and development of asthma, allergy and infections in a birth cohort
Brauer, M; Hoek, G; Smit, HA; de Jongste, JC; Gerritsen, J; Postma, DS; Kerkhof, M; Brunekreef, B
European Respiratory Journal, 29(5): 879-888.
10.1183/09031936.00083406
CrossRef
Thorax
Microsomal epoxide hydrolase, glutathione S-transferase P1, traffic and childhood asthma
Salam, MT; Lin, PC; Avol, EL; Gauderman, WJ; Gilliland, FD
Thorax, 62(): 1050-1057.
10.1136/thx.2007.080127
CrossRef
Science of the Total Environment
The effect of temperature inversions on ground-level nitrogen dioxide (NO2) and fine particulate matter (PM2.5) using temperature profiles from the Atmospheric Infrared Sounder (AIRS)
Wallace, J; Kanaroglou, P
Science of the Total Environment, 407(): 5085-5095.
10.1016/j.scitotenv.2009.05.050
CrossRef
Journal of Dermatological Science
Eczema, respiratory allergies, and traffic-related air pollution in birth cohorts from small-town areas
Kramer, U; Sugiri, D; Ranft, U; Krutmann, J; von Berg, A; Berdel, D; Behrendt, H; Kuhlbusch, T; Hochadel, M; Wichmann, HE; Heinrich, J
Journal of Dermatological Science, 56(2): 99-105.
10.1016/j.jdermsci.2009.07.014
CrossRef
Environmental Health Perspectives
Assessing uncertainty in spatial exposure models for air pollution health effects assessment
Molitor, J; Jerrett, M; Chang, CC; Molitor, NT; Gauderman, J; Berhane, K; McConnell, R; Lurmann, F; Wu, J; Winer, A; Thomas, D
Environmental Health Perspectives, 115(8): 1147-1153.
10.1289/ehp.9849
CrossRef
Environmental Health
Near-highway pollutants in motor vehicle exhaust: A review of epidemiologic evidence of cardiac and pulmonary health risks
Brugge, D; Durant, JL; Rioux, C
Environmental Health, 6(): -.
ARTN 23
CrossRef
Social Science & Medicine
The association between contextual socioeconomic factors and prevalent asthma in a cohort of Southern California school children
Shankardass, K; McConnell, RS; Milam, J; Berhane, K; Tatalovich, Z; Wilson, JP; Jerrett, M
Social Science & Medicine, 65(8): 1792-1806.
10.1016/j.socscimed.2007.05.048
CrossRef
Pharmacology & Therapeutics
Trans-arachidonic acids: new mediators of nitro-oxidative stress
Balazy, M; Chemtob, S
Pharmacology & Therapeutics, 119(3): 275-290.
10.1016/j.pharmthera.2008.05.003
CrossRef
American Journal of Epidemiology
Gene-Environment Interaction in Genome-Wide Association Studies
Murcray, CE; Lewinger, JP; Gauderman, WJ
American Journal of Epidemiology, 169(2): 219-226.
10.1093/aje/kwn353
CrossRef
Atmospheric Environment
Exposure of acid aerosol for schoolchildren in metropolitan Taipei
Mao, IF; Lin, CH; Lin, CJ; Chen, YJ; Sung, FC; Chen, ML
Atmospheric Environment, 43(): 5622-5629.
10.1016/j.atmosenv.2009.07.054
CrossRef
Environmental Health Perspectives
Residential Exposure to Traffic and Spontaneous Abortion
Green, RS; Malig, B; Windham, GC; Fenster, L; Ostro, B; Swan, S
Environmental Health Perspectives, 117(): 1939-1944.
10.1289/ehp.0900943
CrossRef
American Journal of Epidemiology
Bayesian modeling of air pollution health effects with missing exposure data
Molitor, J; Molitor, NT; Jerrett, M; McConnell, R; Gauderman, J; Berhane, K; Thomas, D
American Journal of Epidemiology, 164(1): 69-76.
10.1093/aje/kwj150
CrossRef
Cancer Epidemiology Biomarkers & Prevention
Estimating exposure to polycyclic aromatic hydrocarbons: A comparison of survey, biological monitoring, and geographic information system-based methods
Gunier, RB; Reynolds, P; Hurley, SE; Yerabati, S; Hertz, A; Strickland, P; Horn-Ross, PL
Cancer Epidemiology Biomarkers & Prevention, 15(7): 1376-1381.

Journal of Environmental Health
Potential health effects associated with residential proximity to freeways and primary roads: Review of scientific literature, 1999-2006
Boothe, VL; Shendell, DG
Journal of Environmental Health, 70(8): 33-41.

Pediatrics
Status of Childhood Asthma in the United States, 1980-2007
Akinbami, LJ; Moorman, JE; Garbe, PL; Sondik, EJ
Pediatrics, 123(): S131-S145.
10.1542/peds.2008-2233C
CrossRef
Inhaled Particles X
Home outdoor models for traffic-related air pollutants do not represent personal exposure measurements in Southern California
Ducret-Stich, R; Delfino, RJ; Tjoa, T; Gemperli, A; Ineichen, A; Wu, J; Phuleria, HC; Liu, LJS
Inhaled Particles X, 151(): -.
ARTN 012026
CrossRef
European Respiratory Journal
Does traffic-related air pollution contribute to respiratory disease formation in children?
Jerrett, M
European Respiratory Journal, 29(5): 825-826.
10.1183/09031936.00022607
CrossRef
Inhalation Toxicology
Toxicity of coarse and fine particulate matter from sites with contrasting traffic profiles
Gerlofs-Nijland, ME; Dormans, JAMA; Bloemen, HJT; Leseman, DLAC; Boere, AJF; Kelly, FJ; Mudway, IS; Jimenez, AA; Donaldson, K; Guastadisegni, C; Janssen, NAH; Brunekreef, B; Sandstrom, T; Cassee, FR
Inhalation Toxicology, 19(): 1055-1069.
10.1080/08958370701626261
CrossRef
Environmental Health Perspectives
A cohort study of traffic-related air pollution impacts on birth outcomes
Brauer, M; Lencar, C; Tamburic, L; Koehoorn, M; Demers, P; Karr, C
Environmental Health Perspectives, 116(5): 680-686.
10.1289/ehp.10952
CrossRef
Journal of Environmental Planning and Management
Proximal exposure of public schools and students to major roadways: a nationwide US survey
Appatova, AS; Ryan, PH; LeMasters, GK; Grinshpun, SA
Journal of Environmental Planning and Management, 51(5): 631-646.
10.1080/09640560802208173
CrossRef
Environmental Research
The spatial relationship between traffic-generated air pollution and noise in 2 US cities
Allen, RW; Davies, H; Cohen, MA; Mallach, G; Kaufman, JD; Adar, SD
Environmental Research, 109(3): 334-342.
10.1016/j.envres.2008.12.006
CrossRef
Environmental Health Perspectives
Childhood Incident Asthma and Traffic-Related Air Pollution at Home and School
McConnell, R; Islam, T; Shankardass, K; Jerrett, M; Lurmann, F; Gilliland, F; Gauderman, J; Avol, E; Kunzli, N; Yao, L; Peters, J; Berhane, K
Environmental Health Perspectives, 118(7): 1021-1026.
10.1289/ehp.0901232
CrossRef
Atmospheric Environment
Modeling the intra-urban variability of outdoor traffic pollution in Oslo, Norway - A GA(2)LEN project
Madsen, C; Carlsen, KCL; Hoek, G; Oftedal, B; Nafstad, P; Meliefste, K; Jacobsen, R; Nystad, W; Carlsen, KH; Brunekreef, B
Atmospheric Environment, 41(): 7500-7511.
10.1016/j.atmosenv.2007.05.039
CrossRef
Annals of Allergy Asthma & Immunology
Repeated hospital encounters for asthma in children and exposure to traffic-related air pollution near the home
Delfino, RJ; Chang, J; Wu, J; Ren, C; Tjoa, T; Nickerson, B; Cooper, D; Gillen, DL
Annals of Allergy Asthma & Immunology, 102(2): 138-144.

Thorax
Childhood peak flow and the Oxford Transport Strategy
MacNeill, SJ; Goddard, F; Pitman, R; Tharme, S; Cullinan, P
Thorax, 64(8): 651-656.
10.1136/thx.2008.101360
CrossRef
Journal of Environmental Monitoring
School bus pollution and changes in the air quality at schools: a case study
Li, CL; Nguyen, Q; Ryan, PH; LeMasters, GK; Spitz, H; Lobaugh, M; Glover, S; Grinshpun, SA
Journal of Environmental Monitoring, 11(5): 1037-1042.
10.1039/b819458k
CrossRef
Journal of Environmental Monitoring
Profiling transient daytime peaks in urban air pollutants: city centre traffic hotspot versus urban background concentrations
Moreno, T; Querol, X; Alastuey, A; Viana, M; Gibbons, W
Journal of Environmental Monitoring, 11(8): 1535-1542.
10.1039/b904844h
CrossRef
Annals of Allergy Asthma & Immunology
Relationship between visits to emergency departments for asthma and ozone exposure in greater Seattle, Washington
Mar, TF; Koenig, JQ
Annals of Allergy Asthma & Immunology, 103(6): 474-479.

Bulletin De L Academie Nationale De Medecine
Long-term exposure to urban air pollution measured through a dispersion model and the risk of asthma and allergy in children
Charpin, D; Penard-Morand, C; Raherison, C; Kopferschmitt, C; Lavaud, F; Caillaud, D; Annesi-Maesano, I
Bulletin De L Academie Nationale De Medecine, 193(6): 1317-1328.

Environmental Health Perspectives
Error and bias in determining exposure potential of children at school locations using proximity-based GIS techniques
Zandbergen, PA; Green, JW
Environmental Health Perspectives, 115(9): 1363-1370.
10.1289/ehp.9668
CrossRef
Expert Review of Clinical Immunology
Epidemiology of asthma: risk factors for development
Subbarao, P; Becker, A; Brook, JR; Daley, D; Mandhane, PJ; Miller, GE; Turvey, SE; Sears, MR
Expert Review of Clinical Immunology, 5(1): 77-95.
10.1586/1744666X.5.1.77
CrossRef
European Respiratory Journal
Low levels of air pollution induce changes of lung function in a panel of schoolchildren
Moshammer, H; Hutter, HP; Hauck, H; Neuberger, M
European Respiratory Journal, 27(6): 1138-1143.
10.1183/09031936.06.00089605
CrossRef
Journal of the Air & Waste Management Association
A land use regression model for predicting ambient concentrations of nitrogen dioxide in Hamilton, Ontario, Canada
Sahsuvaroglu, T; Arain, A; Kanaroglou, P; Finkelstein, N; Newbold, B; Jerrett, M; Beckerman, B; Brook, J; Finkelstein, M; Gilbert, NL
Journal of the Air & Waste Management Association, 56(8): 1059-1069.

Journal of the Air & Waste Management Association
Traffic and meteorological impacts on near-road air quality: Summary of methods and trends from the raleigh near-road study
Baldauf, R; Thoma, E; Hays, M; Shores, R; Kinsey, J; Gullett, B; Kimbrough, S; Isakov, V; Long, T; Snow, R; Khlystov, A; Weinstein, J; Chen, FL; Seila, R; Olson, D; Gilmour, I; Cho, SH; Watkins, N; Rowley, P; Bang, J
Journal of the Air & Waste Management Association, 58(7): 865-878.
10.3155/1047-3289.58.7.865
CrossRef
Environmental Health Perspectives
Residential traffic and children's respiratory health
Kim, JJ; Huen, K; Adams, S; Smorodinsky, S; Hoats, A; Malig, B; Lipsett, M; Ostro, B
Environmental Health Perspectives, 116(9): 1274-1279.
10.1289/ehp.10735
CrossRef
Urban Geography
A New Method for Mapping Population and Understanding the Spatial Dynamics of Disease in Urban Areas: Asthma in the Bronx, New York
Maantay, JA; Maroko, AR; Porter-Morgan, H
Urban Geography, 29(7): 724-738.
10.2747/0272-3638.29.7.724
CrossRef
Journal of Epidemiology and Community Health
Neighbourhood socioeconomic status, maternal education and adverse birth outcomes among mothers living near highways
Genereux, M; Auger, N; Goneau, M; Daniel, M
Journal of Epidemiology and Community Health, 62(8): 695-700.
10.1136/jech.2007.066167
CrossRef
Atmospheric Environment
Predicting airborne particle levels aboard Washington State school buses
Adar, SD; Davey, M; Sullivan, JR; Compher, M; Szpiro, A; Liu, LJS
Atmospheric Environment, 42(): 7590-7599.
10.1016/j.atmosenv.2008.06.041
CrossRef
Environmental Health Perspectives
Long-Term Traffic-Related Exposures and Asthma Onset in Schoolchildren in Oslo, Norway
Oftedal, B; Nystad, W; Brunekreef, B; Nafstad, P
Environmental Health Perspectives, 117(5): 839-844.
10.1289/ehp.11491
CrossRef
Pediatric Allergy and Immunology
Residential proximity to main roads during pregnancy and the risk of allergic disorders in Japanese infants: The Osaka Maternal and Child Health Study
Miyake, Y; Tanaka, K; Fujiwara, H; Mitani, Y; Ikemi, H; Sasaki, S; Ohya, Y; Hirota, Y
Pediatric Allergy and Immunology, 21(1): 22-28.
10.1111/j.1399-3038.2009.00951.x
CrossRef
Journal of Investigational Allergology and Clinical Immunology
Urban Air Pollution and Climate Change as Environmental Risk Factors of Respiratory Allergy: An Update
D'Amato, G; Cecchi, L; D'Amato, M; Liccardi, G
Journal of Investigational Allergology and Clinical Immunology, 20(2): 95-102.

European Respiratory Journal
Long-term exposure to close-proximity air pollution and asthma and allergies in urban children
Penard-Morand, C; Raherison, C; Charpin, D; Kopferschmitt, C; Lavaud, F; Caillaud, D; Annesi-Maesano, I
European Respiratory Journal, 36(1): 33-40.
10.1183/09031936.00116109
CrossRef
Bmc Public Health
Influence of geocoding quality on environmental exposure assessment of children living near high traffic roads
Zandbergen, PA
Bmc Public Health, 7(): -.
ARTN 37
CrossRef
Inhalation Toxicology
Health effects of airborne particulate matter: Do we know enough to consider regulating specific particle types or sources?
Grahame, TJ; Schlesinger, RB
Inhalation Toxicology, 19(): 457-481.
10.1080/08958370701382220
CrossRef
Environmental Health
Native and foreign born as predictors of pediatric asthma in an Asian immigrant population: a cross sectional survey
Brugge, D; Lee, AC; Woodin, M; Rioux, C
Environmental Health, 6(): -.
ARTN 13
CrossRef
Journal of Exposure Science and Environmental Epidemiology
Ambient particle source apportionment and daily hospital admissions among children and elderly in Copenhagen
Andersen, ZJ; Wahlin, P; Raaschou-Nielsen, O; Scheike, T; Loft, S
Journal of Exposure Science and Environmental Epidemiology, 17(7): 625-636.
10.1038/sj.jes.7500546
CrossRef
Inhalation Toxicology
Air pollution and respiratory viral infection
Ciencewicki, J; Jaspers, I
Inhalation Toxicology, 19(): 1135-1146.
10.1080/08958370701665434
CrossRef
Allergy
Diagnosis and treatment of asthma in childhood: a PRACTALL consensus report
Bacharier, LB; Boner, A; Carlsen, KH; Eigenmann, PA; Frischer, T; Goetz, M; Helms, PJ; Hunt, J; Liu, A; Papadopoulos, N; Platts-Mills, T; Pohunek, P; Simons, FER; Valovirta, E; Wahn, U; Wildhaber, J
Allergy, 63(1): 5-34.
10.1111/j.1398-9995.2007.01586.x
CrossRef
Environmental Health
Outdoor air pollution and emergency department visits for asthma among children and adults: A case-crossover study in northern Alberta, Canada
Villeneuve, PJ; Chen, L; Rowe, BH; Coates, F
Environmental Health, 6(): -.
ARTN 40
CrossRef
Journal of Exposure Science and Environmental Epidemiology
Passive dosimeters for nitrogen dioxide in personal/indoor air sampling: A review
Yu, CH; Morandi, MT; Weisel, CP
Journal of Exposure Science and Environmental Epidemiology, 18(5): 441-451.
10.1038/jes.2008.22
CrossRef
Revue Des Maladies Respiratoires
Allergic respiratory diseases and outdoor air pollution
Penard-Morand, C; Annesi-Maesano, I
Revue Des Maladies Respiratoires, 25(8): 1013-1026.
10.1019/200820019
CrossRef
Atmospheric Environment
Near roadway concentrations of organic source markers
Olson, DA; Mcdow, SR
Atmospheric Environment, 43(): 2862-2867.
10.1016/j.atmosenv.2009.03.016
CrossRef
Environmental Health Perspectives
Effect of Early Life Exposure to Air Pollution on Development of Childhood Asthma
Clark, NA; Demers, PA; Karr, CJ; Koehoorn, M; Lencar, C; Tamburic, L; Brauer, M
Environmental Health Perspectives, 118(2): 284-290.
10.1289/ehp.0900916
CrossRef
Environmental Health Perspectives
Residential Traffic Exposure, Pulse Pressure, and C-reactive Protein: Consistency and Contrast among Exposure Characterization Methods
Rioux, CL; Tucker, KL; Mwamburi, M; Gute, DM; Cohen, SA; Brugge, D
Environmental Health Perspectives, 118(6): 803-811.
10.1289/ehp.0901182
CrossRef
Inhalation Toxicology
The health relevance of ambient particulate matter characteristics: Coherence of toxicological and epidemiological inferences
Schlesinger, RB; Kunzli, N; Hidy, GM; Gotschi, T; Jerrett, M
Inhalation Toxicology, 18(2): 95-125.
10.1080/08958370500306016
CrossRef
IEEE International Conference on Sensor Networks, Ubiquitous, and Trustworthy Computing, Vol 2, Proceedings
A ubiquitous warning system for asthma-inducement
Chu, HT; Huang, CC; Lian, ZH; Tsai, JJP
IEEE International Conference on Sensor Networks, Ubiquitous, and Trustworthy Computing, Vol 2, Proceedings, (): 186-191.

Thorax
Traffic exposure and lung function in adults: the Atherosclerosis Risk in Communities study
Kan, HD; Heiss, G; Rose, KM; Whitsel, E; Lurmann, F; London, SJ
Thorax, 62(): 873-879.
10.1136/thx.2006.073015
CrossRef
Environmental Health Perspectives
Characterization of source-specific air pollution exposure for a large population-based Swiss Cohort (SAPALDIA)
Liu, LJS; Curjuric, I; Keidel, D; Heldstab, J; Kunzli, N; Bayer-Oglesby, L; Ackermann-Liebrich, U; Schindler, C
Environmental Health Perspectives, 115(): 1638-1645.
10.1289/ehp.10177
CrossRef
Atmospheric Environment
Extended effects of air pollution on cardiopulmonary mortality in Vienna
Neuberger, M; Rabczenko, D; Moshammer, H
Atmospheric Environment, 41(): 8549-8556.
10.1016/j.atmosenv.2007.07.013
CrossRef
Journal of Toxicology and Environmental Health-Part A-Current Issues
Children's response to air pollutants
Bateson, TF; Schwartz, J
Journal of Toxicology and Environmental Health-Part A-Current Issues, 71(3): 238-243.
10.1080/15287390701598234
CrossRef
Environmental Science & Technology
Application of land use regression to estimate long-term concentrations of traffic-related nitrogen oxides and fine particulate matter
Henderson, SB; Beckerman, B; Jerrett, M; Brauer, M
Environmental Science & Technology, 41(7): 2422-2428.
10.1021/es0606780
CrossRef
European Respiratory Journal
Vehicle exhaust outside the home and onset of asthma among adults
Modig, L; Toren, K; Janson, C; Jarvholm, B; Forsberg, B
European Respiratory Journal, 33(6): 1261-1267.
10.1183/09031936.00101108
CrossRef
Occupational and Environmental Medicine
Effect of living close to a main road on asthma, allergy, lung function and chronic obstructive pulmonary disease
Pujades-Rodriguez, M; Lewis, S; Mckeever, T; Britton, J; Venn, A
Occupational and Environmental Medicine, 66(): 679-684.
10.1136/oem.2008.043885
CrossRef
Occupational and Environmental Medicine
Quantitative health impact assessment of transport policies: two simulations related to speed limit reduction and traffic re-allocation in the Netherlands
Schram-Bijkerk, D; van Kempen, E; Knol, AB; Kruize, H; Staatsen, B; van Kamp, I
Occupational and Environmental Medicine, 66(): 691-698.
10.1136/oem.2008.041046
CrossRef
Journal of Exposure Science and Environmental Epidemiology
Analyses of school commuting data for exposure modeling purposes
Xue, JP; McCurdy, T; Burke, J; Bhaduri, B; Liu, C; Nutaro, J; Patterson, L
Journal of Exposure Science and Environmental Epidemiology, 20(1): 69-78.
10.1038/jes.2009.3
CrossRef
Journal of Exposure Science and Environmental Epidemiology
Effects of exposure measurement error in the analysis of health effects from traffic-related air pollution
Baxter, LK; Wright, RJ; Paciorek, CJ; Laden, F; Suh, HH; Levy, JI
Journal of Exposure Science and Environmental Epidemiology, 20(1): 101-111.
10.1038/jes.2009.5
CrossRef
Inhalation Toxicology
The health impact of common inorganic components of fine particulate matter (PM2.5) in ambient air: A critical review
Schlesinger, RB
Inhalation Toxicology, 19(): 811-832.
10.1080/08958370701402382
CrossRef
Cadernos De Saude Publica
Air pollution and respiratory diseases in the municipality of Vitoria, Espirito Santo State, Brazil
de Castro, HA; Hacon, S; Argento, R; Junger, WL; de Mello, CF; Junior, NC; da Costa, JG
Cadernos De Saude Publica, 23(): S630-S642.

Environmental Health Perspectives
Traffic-related air pollution and asthma onset in children: A prospective cohort study with individual exposure measurement
Jerrett, M; Shankardas, K; Berhane, K; Gauderman, WJ; Kunzli, N; Avol, E; Gilliland, F; Lurmann, F; Molitor, JN; Molitor, JT; Thomas, DC; Peters, J; McConnell, R
Environmental Health Perspectives, 116(): 1433-1438.
10.1289/ehp.10968
CrossRef
Environmental Health Perspectives
Particulate Matter (PM) Research Centers (1999-2005) and the Role of Interdisciplinary Center-Based Research
Fanning, EW; Froines, JR; Utell, MJ; Lippmann, M; Oberdorster, G; Frampton, M; Godleski, J; Larson, TV
Environmental Health Perspectives, 117(2): 167-174.
10.1289/ehp.11543
CrossRef
American Journal of Epidemiology
Living near main streets and respiratory symptoms in adults - The Swiss Cohort Study on Air Pollution and Lung Diseases in Adults
Bayer-Oglesby, L; Schindler, C; Hazenkamp-von Arx, ME; Braun-Fahrlander, C; Keidel, D; Rapp, R; Kunzli, N; Braendli, O; Burdet, L; Liu, LJS; Leuenberger, P; Ackermann-Liebrich, U
American Journal of Epidemiology, 164(): 1190-1198.
10.1093/aje/kwj338
CrossRef
Environmental Health
Spatial analysis of air pollution and childhood asthma in Hamilton, Canada: comparing exposure methods in sensitive subgroups
Sahsuvaroglu, T; Jerrett, M; Sears, MR; McConnell, R; Finkelstein, N; Arain, A; Newbold, B; Burnett, R
Environmental Health, 8(): -.
ARTN 14
CrossRef
Indoor Air
Filtration effectiveness of HVAC systems at near-roadway schools
McCarthy, MC; Ludwig, JF; Brown, SG; Vaughn, DL; Roberts, PT
Indoor Air, 23(3): 196-207.
10.1111/ina.12015
CrossRef
Environmental Health Perspectives
Healthy Neighborhoods: Walkability and Air Pollution
Marshall, JD; Brauer, M; Frank, LD
Environmental Health Perspectives, 117(): 1752-1759.
10.1289/ehp.0900595
CrossRef
Environmental Health Perspectives
Environmental Public Health Tracking of childhood asthma using California Health Interview Survey, traffic, and outdoor air pollution data
Wilhelm, M; Meng, YY; Rull, RP; English, P; Balmes, J; Ritz, B
Environmental Health Perspectives, 116(9): 1254-1260.
10.1289/ehp.10945
CrossRef
Science of the Total Environment
Improving spatial concentration estimates for nitrogen oxides using a hybrid meteorological dispersion/land use regression model in Los Angeles, CA and Seattle, WA
Wilton, D; Szpiro, A; Gould, T; Larson, T
Science of the Total Environment, 408(5): 1120-1130.
10.1016/j.scitotenv.2009.11.033
CrossRef
Environmental Research
The association between childhood asthma prevalence and monitored air pollutants in metropolitan areas, United States, 2001-2004
Akinbami, LJ; Lynch, CD; Parker, JD; Woodruff, TJ
Environmental Research, 110(3): 294-301.
10.1016/j.envres.2010.01.001
CrossRef
Journal of Urban Health-Bulletin of the New York Academy of Medicine
Characterizing Urban Traffic Exposures Using Transportation Planning Tools: An Illustrated Methodology for Health Researchers
Rioux, CL; Gute, DM; Brugge, D; Peterson, S; Parmenter, B
Journal of Urban Health-Bulletin of the New York Academy of Medicine, 87(2): 167-188.
10.1007/s11524-009-9419-7
CrossRef
Environmental Health Perspectives
Self-Reported Truck Traffic on the Street of Residence and Symptoms of Asthma and Allergic Disease: A Global Relationship in ISAAC Phase 3
Brunekreef, B; Stewart, AW; Anderson, HR; Lai, CKW; Strachan, DP; Pearce, N
Environmental Health Perspectives, 117(): 1791-1798.
10.1289/ehp.0800467
CrossRef
Environmental Health Perspectives
Traffic, susceptibility, and childhood asthma
McConnell, R; Berhane, K; Yao, L; Jerrett, M; Lurmann, F; Gilliland, F; Kunzli, N; Gauderman, J; Avol, E; Thomas, D; Peters, J
Environmental Health Perspectives, 114(5): 766-772.
10.1289/ehp.8594
CrossRef
European Respiratory Journal
Vehicle exhaust exposure in an incident case-control study of adult asthma
Modig, L; Jarvholm, B; Ronnmark, E; Nystrom, L; Lundback, B; Andersson, C; Forsberg, B
European Respiratory Journal, 28(1): 75-81.
10.1183/09031936.06.00071505
CrossRef
Indoor Air
Indoor and outdoor concentrations and determinants of NO2 in a cohort of 1-year-old children in Valencia, Spain
Esplugues, A; Ballester, F; Estarlich, M; Llop, S; Fuentes, V; Mantilla, E; Iniguez, C
Indoor Air, 20(3): 213-223.
10.1111/j.1600-0668.2010.00646.x
CrossRef
Environmental Science & Technology
A spatial model of urban winter woodsmoke concentrations
Larson, T; Su, J; Baribeau, AM; Buzzelli, M; Setton, E; Brauer, M
Environmental Science & Technology, 41(7): 2429-2436.
10.1021/es0614060
CrossRef
Lifetime Data Analysis
Multistage sampling for latent variable models
Thomas, DC
Lifetime Data Analysis, 13(4): 565-581.
10.1007/s10985-007-9061-1
CrossRef
European Journal of Public Health
Increased health risks of children with single mothers: the impact of socio-economic and environmental factors
Scharte, M; Bolte, G
European Journal of Public Health, 23(3): 469-475.
10.1093/eurpub/cks062
CrossRef
American Journal of Epidemiology
The Association of Ambient Air Pollution and Traffic Exposures With Selected Congenital Anomalies in the San Joaquin Valley of California
Padula, AM; Tager, IB; Carmichael, SL; Hammond, SK; Lurmann, F; Shaw, GM
American Journal of Epidemiology, 177(): 1074-1085.
10.1093/aje/kws367
CrossRef
Science of the Total Environment
Air pollution and respiratory symptoms among children with asthma: Vulnerability by corticosteroid use and residence area
Lewis, TC; Robins, TG; Mentz, GB; Zhang, XH; Mukherjee, B; Lin, XH; Keeler, GJ; Dvonch, JT; Yip, FYY; O'Neill, MS; Parker, EA; Israel, BA; Max, PT; Reyes, A
Science of the Total Environment, 448(): 48-55.
10.1016/j.scitotenv.2012.11.070
CrossRef
International Journal of Occupational Medicine and Environmental Health
Effect of Residential Proximity to Traffic on Respiratory Disorders in School Children in Upper Silesian Industrial Zone, Poland
Skrzypek, M; Zejda, JE; Kowalska, M; Czech, EM
International Journal of Occupational Medicine and Environmental Health, 26(1): 83-91.
10.2478/S13382-013-0078-2
CrossRef
Urban Environmental Pollution 2010
In vitro effects of microbiologically characterized Milan particulate matter
Maurizio, G; Andrea, F; Eleonora, L; Paride, M; Giuseppina, B; Ezio, B; Marina, C
Urban Environmental Pollution 2010, 4(): 192-197.
10.1016/j.proenv.2011.03.023
CrossRef
Environmental Research
Environmental pollution in Mongolia: Effects across the lifespan
Warburton, D; Gilliland, F; Dashdendev, B
Environmental Research, 124(): 65-66.
10.1016/j.envres.2013.04.002
CrossRef
The American Journal of the Medical Sciences
Outdoor Air Pollution: Nitrogen Dioxide, Sulfur Dioxide, and Carbon Monoxide Health Effects
Chen, T; Gokhale, J; Shofer, S; Kuschner, WG
The American Journal of the Medical Sciences, 333(4): 249-256.
10.1097/MAJ.0b013e31803b900f
PDF (181) | CrossRef
Current Opinion in Pulmonary Medicine
Asthma and air quality
Sarnat, JA; Holguin, F
Current Opinion in Pulmonary Medicine, 13(1): 63-66.
10.1097/MCP.0b013e3280117d25
PDF (88) | CrossRef
Epidemiology
An Attributable Risk Model for Exposures Assumed to Cause Both Chronic Disease and its Exacerbations
Künzli, N; Perez, L; Lurmann, F; Hricko, A; Penfold, B; McConnell, R
Epidemiology, 19(2): 179-185.
10.1097/EDE.0b013e3181633c2f
PDF (378) | CrossRef
Journal of Occupational and Environmental Medicine
The Influence of Neighborhood Roadways on Respiratory Symptoms Among Elementary Schoolchildren
Dales, R; Wheeler, AJ; Mahmud, M; Frescura, A; Liu, L
Journal of Occupational and Environmental Medicine, 51(6): 654-660.
10.1097/JOM.0b013e3181a0363c
PDF (232) | CrossRef
Back to Top | Article Outline

Supplemental Digital Content

Back to Top | Article Outline

© 2005 Lippincott Williams & Wilkins, Inc.

Twitter  Facebook

Login

Article Tools

Images

Share