Brain Tumors and Salivary Gland Cancers Among Cellular Telephone Users
Auvinen, Anssi1; Hietanen, Maila2; Luukkonen, Ritva3; Koskela, Riitta-Sisko3
From the 1Finnish Cancer Registry and STUK-Radiation and Nuclear Safety Authority, and
2Finnish Institute of Occupational Health, Department of Physics, and
3Department of Epidemiology and Biostatistics, Helsinki, Finland.
Address correspondence to: Maila Hietanen, Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, FIN-00250 Helsinki, Finland; maila.hietanen@ occuphealth.fi
This study was supported by the Finnish National Technology Agency (TEKES) research program, “Electromagnetic Fields from Mobile Phones as a Possible Health Risk.” Finnish mobile phone manufacturers and network providers contributed to the funding for the TEKES research program.
Submitted 28 June 2001; final version accepted 10 January 2002.
Background. Possible risk of cancer associated with use of cellular telephones has lately been a subject of public debate.
Methods. We conducted a register-based, case-control study on cellular phone use and cancer. The study subjects were all cases of brain tumor (N = 398) and salivary gland cancer (N = 34) diagnosed in Finland in 1996, with five controls per case.
Results. Cellular phone use was not associated with brain tumors or salivary gland cancers overall, but there was a weak association between gliomas and analog cellular phones.
Conclusions. A register-based approach has limited value in risk assessment of cellular phone use owing to lack of information on exposure.
The current number of mobile phone users worldwide is approximately 500 million. 1 Possible health hazards of radiofrequency (RF) electromagnetic fields emitted by cellular phones have been a subject of public debate. Possible carcinogenic effect of RF electromagnetic fields has been a special concern, but few epidemiologic studies on the subject have been published. 2–6 We conducted a population-based, case-control study on mobile phone use and brain tumors and salivary gland cancers with exposure assessment based on cellular network company records.
The ethical committee of the Finnish Institute of Occupational Health approved the study protocol, and the National Research and Development Centre for Welfare and Health granted permission for use of cancer register data.
We identified all 398 brain tumors (198 gliomas, 129 meningiomas, and 72 other or unspecified types, excluding lymphomas) and 34 salivary gland cancers diagnosed in patients between 20 and 69 years of age in Finland in 1996 from the population-based Finnish Cancer Registry. The glioma group comprised astrocytomas, glioblastomas, oligodendrogliomas, oligoastrocytomas, and ependymomas. Eighty-eight percent of brain tumors (all of the gliomas and meningiomas, and 45% of other tumors) and 97% of salivary gland cancers were microscopically confirmed.
We selected five age- and sex-matched controls for each tumor case from the Population Registry Centre of Finland. Four controls were excluded because of a previous diagnosis of brain tumor. The mean age of both brain tumor cases and controls was 50.5 years; 56% were women. For salivary gland cancer cases and controls, the mean age was 52.6 years and 38% were women.
We also compared the location and histologic subtype of gliomas among cases with and without cellular phone subscription. We reviewed cancer register notifications for all 32 cases with a cellular phone subscription before 1996 (22 with analog, six with digital, and four with both), and compared these with 32 age- and sex-matched cases without cellular phone subscription.
We identified all private subscribers (>500,000 subjects) to the cellular phone networks in Finland. Information on cellular phone subscriptions for the cases and controls was obtained from the two cellular network providers operating in Finland in 1996. We used a computerized record linkage, based on the personal identification number, to identify cases and controls with cellular network subscriptions. We obtained information on the type of subscription (analog [transmitting constant RF signal] or digital [transmitting pulsed RF signal] 900 MHz system), and the start and end date of subscription. Use of 450 MHz analog phones was excluded, because these usually had a separate transmission unit (“bag phone”) with little or no RF field exposure to the users. Subjects with multiple accounts were identified. For persons who had switched from analog phones to digital phones (N = 18), duration of use for each type of phone was considered in the analyses.
Potential Confounding Factors
Potential confounders were urban residence, socioeconomic status, and occupation either in farming or with exposure to electromagnetic fields. We obtained information on place of residence from the Population Registry Centre, and information on occupation and socioeconomic status from Statistics Finland based on the 1990, 1993, and 1995 censuses. No information on occupation was available for 20% of cases and 18% of controls. Occupations, socioeconomic status, and places of residence were similar for controls and subjects with brain tumors (Table 1). A smaller proportion of salivary gland cancer patients than controls were farmers. Prior radiotherapy to the head and neck was reported at the cancer register for only three brain tumor cases (two hemangiomas and one meningioma) and four controls.
Adjusted odds ratios (ORs) were calculated using conditional logistic regression. The 95% confidence intervals (CIs) presented are likelihood based.
The statistical power of the study was sufficient to detect an odds ratio of 1.4 or higher for brain tumors and 2.8 or higher for salivary gland cancers (with α = 0.05, two-sided and 1-β = 0.8).
Thirteen percent of brain tumor cases, 12% of salivary gland cancer cases, and 11% of the controls had ever had a personal subscription to a cellular phone network (Table 2). Average duration of subscription was 2–3 years for the analog system, but less than 1 year for the digital phones.
Odds ratios of 1.3 (95% CI = 0.9–1.8) for brain tumors and 1.3 (95% CI = 0.4–4.7) for salivary gland cancers were observed for ever having a cellular phone subscription (Table 3). Gliomas had a weak association with cellular phone use (OR = 1.5; 95% CI = 1.0–2.4), whereas meningiomas (OR = 1.1; 95% CI = 0.5–2.4) and other histologic types (OR = 0.9; 95% CI = 0.4–2.0) were not associated with cellular phone use. In analyses by phone type, gliomas were associated with use of analog phones (OR = 2.1; 95% CI = 1.3–3.4), but not digital phones (OR = 1.0; 95% CI = 0.5–2.0). We found a weak, increasing trend in ORs by duration of analog phone subscription for gliomas, when duration was used as a continuous variable (OR = 1.2 per year; 95% CI = 1.1–1.5), but not among ever users of mobile phones, when duration was classified into three groups (Table 3). No such trend was found for digital phones. No association with duration of analog phone subscription was found for meningiomas (OR = 1.0; 95% CI = 0.6–1.5), or salivary gland cancers (OR = 1.3; 95% CI = 0.7–2.5). The results concerning brain tumors remained similar after adjustment for place of residence, occupation, and socioeconomic status.
In a detailed analysis of histologic type and tumor location (lobe and laterality), no differences were observed between exposed and unexposed glioma cases (Table 4).
Few epidemiologic studies have been published on the effects of cellular phone use on cancer risk. Two previous cohort studies and three case-control studies have not found an association between brain tumors and use of cellular phones. 2–6
We designed a case-control study based on the entire Finnish population 20–69 years of age in 1996. To maximize the duration of exposure and latency, the latest year available at the cancer register was selected. We restricted the age range to 20–69 years because use of mobile phones is most common in this age group.
A register-based approach avoids recall bias, as well as selection bias related to nonresponse. However, we were not able to verify that the actual user of the cellular phone was the subscriber or someone else (such as a family member). In a study conducted in the United States, the cellular phone subscriber was the primary phone user in 69% of subscriptions and was the sole user in 48%. 7 We also had no information on the frequency or duration of calls, or on cellular phones provided by companies to their employees. Before 1996, there were more corporate than private subscriptions in Finland, and therefore more than half of all cellular phone users could have been classified as nonusers in this study. Low sensitivity and specificity of exposure tend to attenuate exposure effect. However, 50% sensitivity in exposure assessment would have attenuated the effect by only about 10%, assuming a reference exposure prevalence of 20% and a true OR of 1.1–2.0.
In conclusion, information obtained directly from subjects on mobile phone use seems preferable to a register-based approach, which has insufficient level of information. An ongoing international collaborative study with exposure assessment based on personal interview rather than registries may provide more accurate results within a few years. 8 Future studies of these cancers with larger numbers of study subjects, more detailed exposure assessment, and longer periods of exposure and follow-up are needed for valid risk assessment.
We thank the Finnish Cancer Registry for the cancer data, Statistics Finland for the data on occupation and socioeconomic status, the Population Registry Centre for identifying the controls and providing data on vital status, and Sonera and Radiolinja for the provision of information on cellular phone subscriptions. We also thank the former Research Director, Sven Hernberg, and Professor Jorma Rantanen, Finnish Institute of Occupational Health, for their comments on the manuscript, and we gratefully acknowledge the assistance of Anna-Maija Hämäläinen throughout the study.
1. Independent Expert Group on Mobile Phones. Mobile Phones and Health. Chilton: National Radiological Protection Board, 2000.
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3. Dreyer NA, Loughlin JE, Rothman KJ. Cause-specific mortality in cellular phone users. JAMA 1999; 282: 1814–1816.
4. Muscat JE, Malkin MG, Thompson S, et al. Handheld cellular telephone use and risk of brain cancer. JAMA 2000; 284: 3001–3007.
5. Inskip PD, Tarone RE, Hatch EE, et al. Cellular telephone use and brain tumors. N Engl J Med 2001; 344: 79–86.
6. Johansen C, Boice JD Jr, McLaughlin JK, Olsen JH. Cellular telephones and cancer—a nationwide cohort study in Denmark. J Natl Cancer Inst 2001; 93: 203–207.
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brain neoplasms; salivary gland neoplasms; cellular telephones; radiofrequency fields
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