Skip Navigation LinksHome > July 2013 - Volume 24 - Issue 4 > Long- and Short-Term Exposure to PM2.5 and Mortality: Using...
Epidemiology:
doi: 10.1097/EDE.0b013e318294beaa
Air Pollution

Long- and Short-Term Exposure to PM2.5 and Mortality: Using Novel Exposure Models

Kloog, Itaia; Ridgway, Billb; Koutrakis, Petrosa; Coull, Brent A.c; Schwartz, Joel D.a

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Abstract

Background: Many studies have reported associations between ambient particulate matter (PM) and adverse health effects, focused on either short-term (acute) or long-term (chronic) PM exposures. For chronic effects, the studied cohorts have rarely been representative of the population. We present a novel exposure model combining satellite aerosol optical depth and land-use data to investigate both the long- and short-term effects of PM2.5 exposures on population mortality in Massachusetts, United States, for the years 2000–2008.

Methods: All deaths were geocoded. We performed two separate analyses: a time-series analysis (for short-term exposure) where counts in each geographic grid cell were regressed against cell-specific short-term PM2.5 exposure, temperature, socioeconomic data, lung cancer rates (as a surrogate for smoking), and a spline of time (to control for season and trends). In addition, for long-term exposure, we performed a relative incidence analysis using two long-term exposure metrics: regional 10 × 10 km PM2.5 predictions and local deviations from the cell average based on land use within 50 m of the residence. We tested whether these predicted the proportion of deaths from PM-related causes (cardiovascular and respiratory diseases).

Results: For short-term exposure, we found that for every 10-µg/m3 increase in PM 2.5 exposure there was a 2.8% increase in PM-related mortality (95% confidence interval [CI] = 2.0–3.5). For the long-term exposure at the grid cell level, we found an odds ratio (OR) for every 10-µg/m3 increase in long-term PM2.5 exposure of 1.6 (CI = 1.5–1.8) for particle-related diseases. Local PM2.5 had an OR of 1.4 (CI = 1.3–1.5), which was independent of and additive to the grid cell effect.

Conclusions: We have developed a novel PM2.5 exposure model based on remote sensing data to assess both short- and long-term human exposures. Our approach allows us to gain spatial resolution in acute effects and an assessment of long-term effects in the entire population rather than a selective sample from urban locations.

© 2013 by Lippincott Williams & Wilkins, Inc

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