Skip Navigation LinksHome > July 2013 - Volume 24 - Issue 4 > Hyperuricemia After Exposure to Polychlorinated Dibenzo-P-Di...
doi: 10.1097/EDE.0b013e318294ef68

Hyperuricemia After Exposure to Polychlorinated Dibenzo-P-Dioxins and Dibenzofurans Near a Highly Contaminated Area

Chang, Jung-Weia; Ou, Horng-Yihb; Chen, Hsiu-Lingc; Su, Huey-Jena,d; Lee, Ching-Changa,d

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Background: Hyperuricemia (too much uric acid in the blood) is the predisposing condition for gout and is associated with hypertriglyceridemia, diabetes mellitus, and coronary artery disease. Polychlorinated dibenzo-p-dioxins and dibenzo-furans (PCDD/Fs) cause renal toxicity and elevate uric acid. The aim of this analysis was to investigate and clarify the effect of moderate-to-high PCDD/F exposure on hyperuricemia risk.

Methods: In this cross-sectional study, we recruited 1531 healthy participants living near a deserted pentachlorophenol factory. We measured serum levels of 17 2,3,7,8-substituted PCDD/Fs, and then examined associations between the main predictor variable, serum TEQDF-2005 (total PCDD/Fs 2005 World Health Organization [WHO] toxic equivalency [TEQ]), and dependent variables such as uric acid, glomerular filtration rates, and hyperuricemia risk.

Results: We observed a strong monotonic inverse relationship between serum TEQDF-2005 quartiles and the estimated glomerular filtration rate after adjusting for confounding factors (Men: β were 0, −4.7, −6.2, and −14.8; Women: β were 0, −6.7, −12.9, and −21.5). In addition, we observed a suggestive positive trend between serum TEQDF-2005 quartiles and uric acid only in men after adjusting for confounding factors (Men: β were 0, 0.40, 0.36, and 0.59; Pfor trend <0.05). Men with serum TEQDF-2005 higher than the reference group’s (<7.4 pg WHO2005–TEQDF/g lipid) had a higher hyperuricemia risk after adjusting for confounding factors (25th to <50th percentile, adjusted odds ratio [AOR] = 2.20 [95% confidence interval {CI} = 1.30–3.73]; 50th to <75th percentile, AOR = 1.86 [95% CI = 1.08–3.22]; ≥75th percentile, AOR = 3.00 [95% CI = 1.69–5.31]).

Conclusions: We conclude that serum TEQDF-2005 is an important determinant of serum uric acid levels and heightens the risk of hyperuricemia in general populations.

© 2013 by Lippincott Williams & Wilkins, Inc

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