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Epidemiology:
doi: 10.1097/EDE.0b013e31821c6c58
Air Pollution: Original Article

Particulate Air Pollution Exposure and C-reactive Protein During Early Pregnancy

Lee, Pei-Chena; Talbott, Evelyn O.a; Roberts, James M.a,b; Catov, Janet M.a,b; Sharma, Ravi K.c; Ritz, Beated

Supplemental Author Material
Erratum

Erratum

Reference

Lee P-C. Particulate air pollution exposure and C-reactive protein during early pregnancy. Epidemiology. 2011;22:524–531.

Throughout the paper, the unit of measure for C-reactive protein is given as nanograms per milliliter. This should instead be micrograms per milliliter. In addition, under the exposure assessment section, the grid size is given as 13.4 square meters and this should instead be 0.46 square miles.

Epidemiology. 22(5):752, September 2011.

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Abstract

Background: It is not well understood how air pollution leads to adverse pregnancy outcomes. One pathway may be through C-reactive protein, a biomarker of systemic inflammation that has been reported to increase the risk of preterm delivery. We examined whether air pollution influences serum concentrations of C-reactive protein in early pregnancy.

Methods: We studied 1696 pregnant women in Allegheny County, PA, from 1997 through 2001. C-reactive protein concentrations were assayed in blood collected before the 22nd week of gestation. We estimated levels of particles of less than 10 μm (PM10) and less than 2.5 μm diameter (PM2.5), carbon monoxide, nitrogen dioxide, sulfur dioxide, and ozone at the maternal zip code using Kriging interpolation for measurements obtained from ambient stations. Associations between air pollution and high C-reactive protein concentrations (≥8 ng/mL) were evaluated using logistic regression.

Results: Among nonsmokers, an observed 9.2 μg/m3 increase in PM10 (averaged over 28 days prior to the blood sample) was associated with an odds ratios of 1.41 for high C-reactive protein concentrations (95% confidence interval = 0.99–2.00). Similarly, a 4.6 μg/m3 increase in PM2.5 was associated with an odds ratio of 1.47 (1.05–2.06). The odds ratio was 1.49 (0.75–2.96) per 7.9 ppb increase in ozone during summer. There were no associations in smokers or for other air pollutants, and there was no evidence for effect-measure modification by obesity.

Conclusions: PM10, PM2.5, and ozone exposures were associated with increased C-reactive protein concentrations in early pregnancy, suggesting that these air pollutants contribute to inflammation and thereby possibly to adverse pregnancy outcomes.

© 2011 Lippincott Williams & Wilkins, Inc.

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