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Sex of Prior Children and Risk of Stillbirth in Subsequent Pregnancies

Nielsen, Henriette Svarrea,b; Mortensen, Laust H.a; Nygaard, Ulrikkac; Schnor, Olea; Christiansen, Ole Bjarneb; Andersen, Anne-Marie N.d

doi: 10.1097/EDE.0b013e3181c04dcf
Perinatal: Brief Report

Background: Delivery of a boy has been reported to increase a woman's risk of recurrent miscarriage in subsequent pregnancies. We explored whether delivery of boys similarly increases the risk of a subsequent stillbirth.

Methods: We identified all Danish women delivering their first child (singleton) between 1980 and 1998 (n = 499,731) using the Danish Birth Registry. These women had subsequent singleton births through 2004 (n = 558,314). We assessed the risk of stillbirth conditional on sex of prior children.

Results: The risk of stillbirth was increased by 12% after deliver of boys compared with girls (relative risk = 1.12 [95% confidence interval = 1.02–1.23]). This association did not appear to be explained by maternal confounders.

Conclusion: Stillbirth risk appears to be slightly higher among the pregnancies of women who have previously delivered a boy. One possible mechanism is maternal immune response to male-specific minor histocompatibility antigens initiated during pregnancies with boys.

From the aThe National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark; bThe Fertility Clinic, and cDepartment of Neonatology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; and dDivision of Epidemiology, University of Southern Denmark, Odense, Denmark.

Submitted 14 December 2008; accepted 3 March 2009; posted 9 November 2009.

Supported by a research grant from the Copenhagen University Hospital, Rigshospitalet (to H.S.N.).

Correspondence: Henriette S. Nielsen, The Fertility Clinic, Copenhagen University Hospital, Rigshospitalet, DK-2100 Copenhagen Ø, Denmark. E-mail: henriette.svarre.nielsen@rh.regionh.dk.

© 2010 Lippincott Williams & Wilkins, Inc.