Improved Air Quality in Reunified Germany and Decreases in Respiratory Symptoms

Heinrich, Joachim1; Hoelscher, Bernd1; Frye, Christian1; Meyer, Ines1; Pitz, Mike1 2; Cyrys, Josef2; Wjst, Matthias1; Neas, Lucas3; Wichmann, H.-Erich1 2

Original Articles

Background. Previous research on air pollution effects has found associations with chronic adverse health effects even at the relatively low levels of ambient particulates currently measured in most urban areas.

Methods. We assessed the impact of declines of total suspended particulates and sulfur dioxide in eastern Germany after reunification on the prevalence of nonallergic respiratory disorders in children. In the 1990s, particle mass (total suspended particulates) and sulfur dioxide declined, whereas number concentrations of nucleation-mode particles (10–30 nm) increased. In three study areas, questionnaires for 7,632 children between 5 and 14 years of age were collected in three phases: 1992–1993, 1995–1996, and 1998–1999.

Results. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for a 50-μg/m3 increment in total suspended particulates were 3.0 (CI = 1.7–5.3) for bronchitis, 2.6 (CI = 1.0–6.6) for sinusitis, and 1.9 (CI = 1.2–3.1) for frequent colds. The effect sizes for a 100-μg/m3 increment in sulfur dioxide were similar. The effect estimates for ambient total suspended particulates and sulfur dioxide were stronger among children not exposed to gas stove emissions, visible molds or dampness, cats, or environmental tobacco smoke.

Conclusions. The decreasing prevalence of nonallergic respiratory symptoms, along with improvements in ambient particle mass and sulfur dioxide (but not in nucleation-mode particles), indicates the reversibility of adverse health effects in children. This adds further evidence of a causal association between combustion-related air pollutants and childhood respiratory symptoms.

From the 1GSF, National Research Center for Environment and Health Institute for Epidemiology;

2Ludwig-Maximilians-University, University of Munich, Neuherberg, Germany; and

3United States Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Research Triangle Park, NC.

Address correspondence to: Joachim Heinrich, GSF-Institute of Epidemiology, P.O. Box 1129, D-85758 Oberschleissheim, Germany; Joachim.Heinrich@gsf.de

This study was supported exclusively by a German governmental funding source, the Federal Environmental Agency (Umweltbundesamt) Grants 298 61 724, 116 09 002, and 116 09 002/02.

The contents of this paper do not necessarily reflect the views or policies of the U.S. Environmental Protection Agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use.

Submitted 24 May 2001; final version accepted 06 March 2002.

Editors’ note: An invited commentary on this article appears on page 376.

© 2002 Lippincott Williams & Wilkins, Inc.